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Pathoma: Fundamentals of Pathology (2018)
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Disorders of Pigmentation & Melanocytes

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Pathoma: Fundamentals of Pathology (2018) | Medicine (MD/DO) School Study Aid

Disorders of Pigmentation & Melanocytes
8 Picmonics to Learn | 13 mins
Vitiligo
Pathophysiology
Autoimmune Destruction of Melanocytes
Presentation
Hypopigmentation
Acral Areas and Around Orifices
Diagnosis
Clinical Presentation + Woods Lamp
Risk Factors
Other Autoimmune Diseases
Treatment
Glucocorticoids
Tacrolimus
Phototherapy
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2 mins
Chediak-Higashi Syndrome
Pathophysiology
Autosomal Recessive
Defective Lysosomal Trafficking Regulator Gene (LYST)
Defect In Microtubular Function
Decrease In Phagocytosis
Signs And Symptoms
Recurrent Pyogenic Infections
Staph Aureus And Streptococci
Partial Albinism
Peripheral Neuropathy
Pancytopenia
Diagnosis
Giant Granules In Granulocytes And Platelets
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2 mins
Melanocytic Nevus
Characteristics
Benign Tumor of Melanocytes
Nested Proliferations at Dermal-Epidermal Junction
Junctional
Intradermal
Risk Factors
Genetics
Childhood Sun Exposure
Considerations
Melanoma
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2 mins
Melanoma Mechanism and Characteristics
Mechanism
Associated with Sunlight Exposure
Mutation in B-RAF kinase
Large Number of Moles
Fair-Skinned People at Higher Risk
Growth Phases
Radial Growth Phase
No Metastasis
Vertical Growth Phase
Depth of Tumor Correlates with Risk of Metastasis
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1 min
ABCDEs of Melanoma
Asymmetry
Border
Color
Diameter
Evolving
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1 min
Melanoma Diagnosis
Signs
ABCDE Mnemonic
Asymmetry
Border irregularity
Color variation
Diameter > 6mm
Evolution over time
Diagnosis
S-100 Tumor Marker
LDH (Lactate Dehydrogenase) Screens for Metastasis
Treatment
Wide Local Excision
Adjuvant Therapy
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1 min
Types of Malignant Melanoma
Superficial Spreading
Most Common Cause of Melanoma
Nodular
Aggressive and Rapidly Arising
Acral-Lentiginous
Males
Asians and African Americans
Lentigo Maligna
Geographic Shape
Sun Exposed Areas
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2 mins
Seborrheic Keratosis
Features
Flat, Greasy, Pigmented Squamous Epithelium
"Stuck-On" Appearance
Horn Cysts
Proliferation of Immature Keratinocytes
Most Common Benign Tumor in the Elderly
Location
Head, Trunk, and Extremities
Considerations
GI Adenocarcinoma
Leser-Trelat Sign
Treatment
Observation
Cryotherapy
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2 mins

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