Pharmacotherapeutics for Advanced Nursing Practice, 1st. Ed., Demler & Rhoads, 2018 | Nurse Practitioner (NP) School Study Aid
Migraine Headaches Signs and Symptoms
- More Common in Women
- Exacerbated by Activity
- Unilateral Pulsating Pain
- Aura
- Photophobia and Phonophobia
- Nausea/Vomiting
- 4 hours to 3 Days
Migraine Headache Treatments
- Avoid Triggers
- Sumatriptan
- NSAIDs
- Beta Blockers
- Calcium Channel Blockers
- Amitriptyline
- Topiramate (Anticonvulsants)
Sumatriptan
- Short Half-Life
- 5-HT Agonist
- Inhibits Trigeminal Nerve Activation
- Induces Vasoconstriction
- Migraine
- Cluster Headache
- Increased Risk of Serotonin Syndrome
- Paresthesias
- Coronary Vasospasm
- Prinzmetal's Angina
- Coronary Artery Disease (CAD)
Acetaminophen
- Fever
- Pain
- Reversibly Inhibits COX
- Acts Primarily in CNS
- Hepatic Necrosis
- N-acetylcysteine Antidote
Butorphanol
- Migraine
- Severe Pain
- Labor
- Partial Agonist at Mu and Full Agonist at Kappa Receptors
- Less Respiratory Depression
- Withdrawal Symptoms
Methylergonovine (Methergine) and Ergotamine (Ergot Alkaloids)
- Smooth Muscle Contraction
- Vasoconstriction
- Migraine
- Postpartum Hemorrhage
- Nausea and Vomiting
- Severe Hypertension
- Tachycardia
- 2nd Line Agent
Nonselective Beta-Blockers
- "-olol" Suffix
- Nonselective
- Propranolol
- Timolol
- Nadolol
- Partial β Agonist
- Pindolol
- Nonselective β with α Blocking
- Carvedilol
- Labetalol
Topiramate
- Seizure Treatment
- Migraine Prophylaxis
- Increase GABA Action
- Blocks Voltage-Gated Na+ Channels
- Kidney Stones
- Weight Loss
- Sedation
Valproic Acid (Valproate) Side Effects
- Vomiting
- Alopecia
- Liver Toxicity
- Pancreatitis/Pancytopenia
- Retain Fat (Weight Gain)
- Oedema (Edema)
- Appetite Increase
- Tremor
- Enzyme Inhibitor (P450)