Pharmacotherapeutics for Advanced Nursing Practice, 1st. Ed., Demler & Rhoads, 2018 | Nurse Practitioner (NP) School Study Aid
Clindamycin
- Bacteriostatic
- Binds 50S Ribosomal Subunit
- Blocks Translocation
- Anaerobic Infections above the Diaphragm
- Aspiration Pneumonia
- Lung Abscess
- Can Cause Pseudomembranous Colitis
Aminoglycosides
- Gentamicin
- Neomycin for Bowel Surgery Prep
- Amikacin
- Tobramycin
- Streptomycin
- Bactericidal
- Inhibit Formation of Initiation Complex
- Cause Misreading of mRNA
- Require O2 for Uptake
- Resistance by Transferase Enzymes
- Acetylation
- Phosphorylation
- Adenylation
- Gram-Negative Rod Infections
- Synergistic with B-Lactam Antibiotics
- Nephrotoxicity Especially When Used with Cephalosporins
- Ototoxicity Especially When Used with Loop Diuretics
- Teratogen
Metronidazole
- Bactericidal
- Forms Free Radical Toxic Metabolites
- Damages DNA
- Giardia lamblia
- Entamoeba Histolytica
- Trichomonas
- Gardnerella
- Anaerobes
- Metallic taste
- Disulfiram like Reaction with Alcohol
Acyclovir (Zovirax)
- Guanosine Analog
- Inhibits Viral Replication
- Thymidine Kinase Activation
- Herpes Simplex Virus (HSV)
- Varicella Zoster Virus (VZV)
- Headache
- GI Distress
- CNS Toxicity
- Nephrotoxicity (Crystalline Nephropathy)
- Prevents Recurrent Episodes
- Slow IV Infusion
Terbinafine
- Dermatophytosis
- Onychomycosis
- Inhibits Squalene Epoxidase
- Hepatotoxicity
- GI Distress
- Taste Disturbances
- Headache
Azoles (Ketoconazole)
- "-azole" suffix
- Local and Less Serious Systemic Mycosis
- Inhibits Ergosterol Synthesis
- Inhibits P450
- Liver Dysfunction
- Inhibition of Testosterone Synthesis
Nystatin
- Candidiasis
- Vaginal
- Oral
- Cutaneous
- Polyene
- Binds Ergosterol
- Forms Membrane Pores
- Topical form of Amphotericin B
- Rash
Silver Sulfadiazine (Silvadene) and Mafenide Acetate (Sulfamylon)
- Topical Antimicrobial
- Burns
- Open Wound Care
- Mafenide
- Pain
- Acidosis
- Administer Analgesic Prior to Wound Care
Prednisone (Glucocorticoids)
- Glucocorticoid
- Inflammatory Conditions
- Organ Transplant Rejection
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Adrenal Insufficiency
- Taper Gradually
Anaphylaxis Intervention
- Assess Airway and Oxygen Needs
- Reassure Patient with Anxiety
- Supine Position
- Methylprednisolone (Solu-medrol)
- Epinephrine
- Diphenhydramine (Benadryl)
- Medical Alert Bracelet
Fluorouracil (5-FU)
- Antimetabolite
- "Thymine-less Death"
- Slow-growing Solid Tumors
- Co-administered with Leucovorin for Stomach Cancer
- Basal Cell Carcinoma (Topical)
- Myelosuppression
- Mucositis
- Severe Diarrhea
Minoxidil (Loniten, Rogaine)
- Vasodilates Arterioles
- Severe Hypertension
- Baldness
- Reflex Tachycardia
- Blood Volume Expansion
- Hypertrichosis
- Pericardial Effusion
- Rash
- Give with Beta Blocker and Diuretic
Tacrolimus (Prograf) Overview
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Transplant Rejection
- Atopic Dermatitis
- Increased Lymphoma Risk
- Avoid Grapefruit Juice
Tacrolimus (Prograf) Side Effects
- Nephrotoxicity
- Neurotoxicity
- GI Distress
- Infection
- Hypertension
- Hyperkalemia
- Hyperglycemia
Lice
- Pediculosis Capitis, Corporis, Pubis
- Pruritis
- Hyperpigmentation
- Trench Fever
- Bartonella Quintana
- Epidemic Typhus
- Rickettsia Prowazekii
- Relapsing Fever
- Borrelia Recurrentis
- Permethrin
- Malathion
- Ivermectin