Tamoxifen
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- ER-positive Breast Cancer
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
Busulfan
- CML
- Bone Marrow Ablation
- Cross-Links DNA
- Myelosuppression
- Pulmonary Fibrosis
- Hyperpigmentation
Cisplatin
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Cross-Links DNA
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
Vincristine (Oncovin)
- Vinca Alkaloid
- Inhibits Microtubules
- Leukemias
- Lymphomas
- Peripheral Neuropathy
- Paralytic Ileus
- Vesicant
Bleomycin
- Testicular Cancer
- Hodgkin's Lymphoma
- Induces Free Radical Formation
- Breaks in DNA Strands
- Pulmonary Fibrosis
- Skin Changes
- Mucositis
Fluorouracil (5-FU)
- Antimetabolite
- "Thymine-less Death"
- Slow-growing Solid Tumors
- Co-administered with Leucovorin for Stomach Cancer
- Basal Cell Carcinoma (Topical)
- Myelosuppression
- Mucositis
- Severe Diarrhea
Dactinomycin (Actinomycin D)
- Wilms' Tumor
- Rhabdomyosarcoma
- Ewing's Sarcoma
- Gestational Trophoblastic Malignancy
- Intercalates DNA
- Myelosuppression
Doxorubicin (Adriamycin)
- Solid Tumors
- Lymphomas and Leukemias
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
Aromatase Inhibitors
- Estrogen Receptor-positive (ER+) Breast Tumors
- Systemic Metastases
- Reversible, non-steroid
- Letrozole
- Anastrozole
- Irreversible, steroid
- Exemestane
- Osteoporosis
- Arthritis
Bevacizumab Mechanisms and Indications
- Monoclonal Antibody to VEGF
- Inhibits Angiogenesis (and Vasculogenesis)
- Capillaries Grow CORN (CG-CORN acronym)
- Colorectal Cancer
- Glioblastoma
- Cervical Cancer
- Ovarian Cancer
- Renal Cell Carcinoma
- Non-small Cell Lung Cancer (NSCLC)
- Age-related Macular Degeneration
Bevacizumab Side Effects
- Impaired (Delayed) Wound Healing
- Hemorrhage
- Nosebleed (Epistaxis)
- GI Perforation
- Thromboembolic Event
- Osteonecrosis of the Jaw
Etoposide
- Small Cell Lung Cancer
- Testicular Cancer
- Inhibits Topoisomerase II
- Errors in DNA Synthesis Cause Apoptosis
- Myelosuppression
- Alopecia
- Hypotension
- Nausea and Vomiting
Hydroxyurea
- Inhibits Ribonucleotide Reductase
- Decreased DNA Synthesis
- S-phase Specific
- Melanoma
- Chronic Myelogenous Leukemia (CML)
- Sickle Cell Disease
- Through Increased HbF (Fetal Hemoglobin)
- Myelosuppression
- GI Distress
Imatinib (Gleevec)
- Chronic Myelogenous Leukemia (CML)
- Inhibitor of BCR-ABL Tyrosine Kinase
- Caused by Philadelphia Chromosome
- GI Stromal Tumors
- Inhibitor of C-kit Tyrosine Kinase
- Fluid Retention
Trastuzumab
- HER-2+ Breast Cancer
- Stomach Cancer
- Monoclonal Antibody Against HER-2
- Inhibition of Cellular Signaling
- Cytotoxicity
- Cardiotoxicity
Rituximab
- Chronic Lymphocytic Leukemia (CLL)
- Non-Hodgkin Lymphoma
- Rheumatoid Arthritis
- Microscopic Polyangiitis (MPA)
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Monoclonal Antibody Against CD20
- Found on B Cell Neoplasms
- Infusion Reactions
- Skin and Mouth Reactions
- Reactivation of Hepatitis B Virus (HBV)
- Progressive Multifocal Leukoencephalopathy (PML)
Cyclophosphamide
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
Cetuximab and Panitumumab
- Monoclonal Antibodies Against EGFR
- Colorectal Cancer
- Head and Neck Cancer
- Ménétrier Disease
- Elevated LFTs
- Rash
- Diarrhea
- Hypokalemia
- Hypomagnesemia
Paclitaxel (Taxanes)
- Taxane
- Stabilizes Microtubules
- Breast Cancer
- Ovarian Cancer
- Non-Small Cell Lung Cancer
- Kaposi Sarcoma (HHV-8)
- Mucositis
- Myelosuppression
- Peripheral Neuropathy
- Hypersensitivity
- Alopecia
- Diphenhydramine (Benadryl)
Rasburicase
- Recombinant Uricase
- Converts Uric Acid to Allantoin
- Hyperuricemia
- Tumor Lysis Syndrome
- Hypersensitivity Reaction
- Methemoglobinemia
- Contraindicated in G6PD Deficiency
BRAF Inhibitors
- BRAF Proto-oncogene
- Serine/Threonine Kinase
- V600E Mutation
- Melanoma
- Non-Hodgkin Lymphoma
- Papillary Thyroid Carcinoma
- Hairy Cell Leukemia
- Dabrafenib
- Vemurafenib