Down Syndrome
- Trisomy 21
- Meiotic Nondisjunction
- Intellectual Disability (Mental Retardation)
- Single palmar crease
- Flat Facies
- Duodenal Atresia
- Hirschsprung's Disease
- Septum Primum Type ASD
- Endocardial Cushion Defects
- Prominent Epicanthal Folds
- Increased Risk of Acute Lymphoblastic Leukemia
- Alzheimer's Disease
Airway, Breathing, Circulation (ABC's)
- Changed Sound of Voice
- "See-saw" Respirations
- Stridor
- Normal Respiratory Rate: 12–20 Breaths/Min
- Use of Accessory Muscles in Respiration
- Cyanosis
- Color of Hands and Digits
- Normal Capillary Refill Time (CRT): 2 Seconds
- Decreased LOC
- Initial ‘Look, Listen and Feel” Assessment
- Emergency Treatment
- Prioritization in Exam Questions
Cerebral Palsy (CP)
- Maternal Infections
- Fetal Hypoxia
- Developmental Delay
- Neurological Dysfunction
- Spasticity
- Dysphagia
- Muscle Relaxants
- Muscle Exercises
- Assistive Devices
- Braces
Phenytoin (Dilantin)
- Blocks Na+ Channels
- Tonic-clonic Seizures
- Ataxia
- Nystagmus
- Sedation
- Gingival Hyperplasia
- Purple Glove Syndrome
- Hirsutism
- Rash
- Anemia
- Individualized Dosing
Diazepam (Valium)
- Anxiety
- Seizures and Status Epilepticus
- Muscle Spasms
- Alcohol Withdrawal
- Dizziness/Vision Changes
- Confusion/Amnesia
- Urinary Incontinence
- Behavioral Changes
- Respiratory Depression
- Flumazenil (Romazicon)
- Fall Precaution
- Do Not Stop Abruptly
Phenobarbital (Barbiturates)
- Barbiturate
- Seizures
- Ataxia
- Paradoxical Excitement
- Fatigue/Drowsiness
- Monitor Plasma Levels
- High Potential for Abuse
Valproic Acid (Depakote)
- Blocks Na+ Channels
- Increases GABA Concentration
- Tonic-clonic Seizures
- Bipolar Disorder
- Migraine Prophylaxis
- Hepatotoxicity
- Blood Dyscrasias
- GI Distress
- Tremor
- Pancreatitis
Carbamazepine (Tegretol)
- Inactivates Na+ Channels
- Seizures
- Bipolar Disorder
- Trigeminal Neuralgia
- Nystagmus
- Ataxia
- Hepatotoxicity
- Blood Dyscrasias
- Water Retention
- Stevens-Johnson Syndrome
- Avoid Grapefruit Juice
Lamotrigine (Lamictal)
- Blocks Na+ Channels
- Seizures
- Bipolar Disorder
- Diplopia
- Stevens-Johnson Syndrome
- Headache
- Aseptic Meningitis
- Nausea and Vomiting
- Screen for Suicide Risk
Long-acting Benzodiazepines
- Lorazepam
- Diazepam
- Clonazepam
- Chlordiazepoxide
- Insomnia
- Anxiety
- Seizures
- Eclampsia
- Alcohol Withdrawal
- Half-life > 24 Hours
- Dependence
Attention-Deficit Hyperactivity Disorder (ADHD) Assessment
- Inattention
- Incomplete Tasks
- Easily Distracted
- Hyperactivity
- Impulsiveness
- Disruptive
- Two Areas of Life
- Onset by Age 12
- Symptoms > 6 Months
Attention-Deficit Hyperactivity Disorder (ADHD) Interventions
- CNS Stimulants
- Amphetamine
- Methylphenidate
- Bupropion (Wellbutrin)
- Atomoxetine (Strattera)
- Guanfacine (Intuniv)
- Manage Disruptive Behavior
- Provide Simple Instructions
Spina Bifida Assessment
- Congenital Malformation of Vertebrae
- Dimple With or Without Hair Tuft
- Lumbar Sac
- Hydrocephalus
- Paralysis
- Identify Type
Spina Bifida Interventions
- Surgery
- Prone Position
- Cover Sac with Moist (Sterile) Dressing
- Measure Head Circumference
- Bulging Fontanel
- Other Congenital Malformations Common
- Bowel Control
- Neurogenic Bladder
Hydrocephalus
- Increased CSF in Ventricles of Brain
- Signs of Increased ICP
- High Pitched Cry
- Irritability
- Opisthotonus
- Increased Head Circumference
- Bulging Fontanel
- Setting Sun Sign
- Seizure Precautions
- Elevate HOB
- CSF Shunt
Meningitis Assessment
- Nausea and Vomiting
- Fever
- Nuchal Rigidity
- Severe Headache
- Purpura
- Seizures
- Photophobia
- Opisthotonus Position
- High-Pitched Cry
- Bulging Fontanel
Meningitis Interventions
- IV Antibiotics
- Dexamethasone
- Analgesics
- Antipyretics
- Closely Monitor for Increased ICP
- Bed Rest
- Preventative Vaccinations
- Droplet-Airborne Precautions
Common Causes of Meningitis: Newborn (0-6 Months)
- Group B Streptococci
- E. coli
- Listeria monocytogenes
Common Causes of Meningitis: Children (6 Months - 6 Years)
- Enteroviruses
- Neisseria meningitidis
- Haemophilus influenzae Type B
- Streptococcus pneumoniae
Types of Seizures
- Tonic-Clonic
- Tonic
- Clonic
- Absence (Petit Mal)
- Myoclonic
- Atonic
- Partial (Focal) Seizure
- Focal Aware (Formerly Called Simple Partial)
- Focal Impaired Awareness (Formerly Called Complex Partial)
Seizure Interventions
- Maintain Airway
- Side-lying Position
- Support Head
- Move to Floor
- Benzodiazepines
- Never Restrain
- No Objects in Mouth
- Document Details
Seizure Precautions
- Reduce Environmental Stimuli
- Identify Triggers
- Aura
- Pad Side Rails
- Bed Lowest Position
- Oxygen and Suction Available
- Monitor Therapeutic Drug Levels
Gabapentin
- Seizure Treatment
- Peripheral Neuropathy
- Postherpetic Neuralgia
- Bipolar Disorder
- Migraine Prophylaxis
- Inhibits Voltage-Gated Ca2+ channels
- Designed as a GABA Analog
- Ataxia
- Sedation
Topiramate
- Seizure Treatment
- Migraine Prophylaxis
- Increase GABA Action
- Blocks Voltage-Gated Na+ Channels
- Kidney Stones
- Weight Loss
- Sedation
Ethosuximide (Zarontin)
- First Line Absence Seizure
- Blocks Thalamic T-Type Ca2+ Channels
- Stevens-Johnson Syndrome
- Fatigue
- Diarrhea
- Blood Dyscrasias
- Do Not Stop Abruptly
Streptococcus Pneumoniae Disease
- Sickle Cell Anemia
- Sepsis in Patients with Splenectomy
- Rusty Sputum
- MOPS
- Meningitis
- Otitis Media
- Pneumonia
- Sinusitis
Streptococcus Pneumoniae Characteristics
- Gram-Positive
- Diplococci
- Lancet-Shaped
- Catalase-Negative
- Optochin-Sensitive
- Bile Soluble
- Alpha-Hemolytic
- Polysaccharide Capsule
- Positive Quellung Reaction
- IgA Protease
Neisseria Meningitidis
- Gram-Negative
- Diplococci
- Chocolate Agar
- Thayer-Martin Media
- VPN
- Oxidase-Positive
- Maltose Fermentation
- Glucose Fermentation
- Endotoxin
- Lipooligosaccharide (LOS) in Membrane
- Polysaccharide Capsule
- IgA Protease
- Waterhouse Friderichsen Syndrome
- Adrenal Insufficiency
- Petechial Rash
- Ceftriaxone
- Rifampin Prophylaxis
Streptococcus agalactiae
- Group B Streptococci
- Gram-Positive
- Cocci
- Beta-Hemolytic
- Bacitracin-Resistant
- Catalase-Negative
- Pyrrolidonyl Arylamidase (PYR) Negative
- Polysaccharide Capsule
- Hippurate Positive (+)
- Produces CAMP Factor
- Enlarges Area of Hemolysis by S. aureus
- Mainly in Babies
- Meningitis
- Pneumonia
- Sepsis
- Colonizes Vagina
- Screen Pregnant Women at 35-37 Weeks
- Penicillin
Haemophilus Influenzae Disease
- Pneumonia
- Cherry Red Epiglottitis
- Meningitis
- Otitis Media
- COPD Exacerbation
- Thumbprint Sign (on X-ray)
- Rifampin Prophylaxis
- Ceftriaxone
Haemophilus influenzae Characteristics
- Gram-Negative
- Coccobacilli
- PRP Capsule in Type B
- Positive Quellung Reaction
- IgA Protease
- Chocolate Agar
- Factor V is NAD
- Factor X is Hematin
- Staph Aureus Provides Factor V
Listeria Monocytogenes Disease
- Soft Cheese
- Pregnant Women Have Flu-Like Symptoms
- Pregnant Women Have GI Symptoms
- Granulomatosis Infantiseptica
- Spontaneous Abortion
- Meningitis
- Monocytes in CSF
- Ampicillin
Listeria Monocytogenes Characteristics
- Gram Positive
- Bacillus
- Intracellular
- Survives in Cold Temperature
- Actin Rocket
- Tumbling Motility
- Catalase-Positive
- Beta-Hemolytic
- Only Gram-Positive with Endotoxin-Like Structure
Common Causes of Meningitis: Adolescent and Adult (6 - 60 Years Old)
- Enteroviruses
- Herpes Simplex Virus (HSV)
- Neisseria meningitidis (#1 Cause in Teens)
- Streptococcus pneumoniae
Common Causes of Meningitis: Elderly (60+ Years Old)
- Streptococcus pneumoniae
- Gram-Negative Rods
- Listeria Monocytogenes
Lumbar Puncture
- CSF Sample
- CSF Pressure
- Empty Bladder
- Side-lying Position
- Between 3rd and 4th Lumbar Vertebrae
- Number Tubes
- Supine Position After Procedure
- Increased ICP (Intracranial Pressure)
- Infection at Puncture Site
Ampicillin and Amoxicillin
- Aminopenicillin
- Broad Spectrum Penicillin
- Gram-Positive and Some Gram-Negative Infections
- Rash
- Diarrhea
- No Effect Against Staph Aureus
- Often combined with Beta Lactamase Inhibitor
- Allergic Reaction
Reye's Syndrome
- Aspirin (Salicylates) to Treat Viral Illness (In Children)
- Cerebral Edema
- Lethargy (Decreased LOC)
- Vomiting
- Liver Failure
- Monitor for Increased ICP
- Mannitol (Osmitrol)
- No Aspirin for Children
Aspirin (Acetylsalicylic Acid)
- Inhibits Platelet Aggregation
- NSAID
- Thrombotic Event Prevention
- General Pain
- Inflammatory Conditions
- Fever
- Pancytopenia
- GI Ulcers
- Bleeding
- Withhold Before Surgery 7-10 Days
- Reye's Syndrome
Aspirin Poisoning (Salicylism) Assessment
- Nausea and Vomiting
- Tinnitus
- Confusion
- Hyperventilation
- Respiratory Alkalosis
- Metabolic Acidosis
- Coma
- Hyperthermia
Muscular Dystrophy
- X-linked Recessive
- Muscle Weakness
- Motor Problems
- Gower Sign
- Large Calves
- Waddling Gait
- Loss of Ambulation
- Cardiac and Respiratory Failure