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Karch’s Focus on Nursing Pharmacology, 9th Ed., Tucker | Registered Nurse (RN) School Study Aid

Neuron Action Potential Initiation

Summation of Signals

-50 mV Threshold Value Reached

Voltage-Gated Sodium Channels Open

Local Depolarization

Na+ Influx

Potassium Channels open

Repolarization

2 mins

Neuron Action Potential Propagation

Unidirectional Depolarization

Absolute Refractory Period In Preceding Na+ Channels

Neighboring Voltage Gate Channels Open

Nodes of Ranvier

Myelination Increases Propagation Speed

Saltatory Conduction

3 mins

Neuron Resting Potential

More Na+ Outside

Sodium-Potassium Pump

K+ Leaks Out

More K+ Inside

About -70mV

Voltage-Gated Sodium Channels are Closed

2 mins

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