Medical-Surgical Nursing, 9th Ed., Ignatavicius & Workman, 2018 | Registered Nurse (RN) School Study Aid
Stomach Digestion
- Chief Cells Secrete Pepsinogen
- Pepsinogen Turned to Pepsin By H+
- Protein Breakdown Begins
- Mucous Cells Secrete Mucus and Bicarbonate
- G Cells Secrete Gastrin
- Gastrin Stimulates Parietal Cell HCl Release
- Parietal Cells Secrete Intrinsic Factor
NSAIDs
- Anti-inflammatory
- Analgesic
- Fever
- Closure of Patent Ductus Arteriosus
- Reversible Inhibition of COX-1 and COX-2
- Block Prostaglandin Synthesis
- Interstitial Nephritis
- Gastric Ulcer
- Renal Ischemia
Cimetidine and Famotidine (H2 Receptor Blockers)
- -tidine Suffix
- H2 Receptor Blocker
- Suppress Gastric Acid Secretion
- Pneumonia
- Anti-androgen Effects
- CNS Changes
Omeprazole (Prilosec)
- "-prazole" Suffix
- Zollinger-Ellison Syndrome
- Gastritis
- Peptic Ulcer
- Gastroesophageal Reflux Disease (GERD)
- Proton Pump Inhibitor (PPI)
- Inhibit H+/K+/ATPase
- Hip Fracture
- Pneumonia
Prednisone (Glucocorticoids)
- Glucocorticoid
- Inflammatory Conditions
- Organ Transplant Rejection
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Adrenal Insufficiency
- Taper Gradually
Macrolides
- End in "-thromycin"
- Bacteriostatic
- Alternative for Penicillin Allergy
- Respiratory Infections
- Pneumonia
- QT Prolongation and Sudden Death
- C.Diff Overgrowth
- GI Distress
- Slow IV Infusion
Ibuprofen (Advil, Motrin)
- NSAID
- COX Inhibitor
- General Pain
- Fever
- Inflammatory Conditions
- GI Ulcers
- Nephrotoxicity
- Rash
- Avoid with Alcohol
- Risk of Thrombotic Event
Peptic Ulcer Disease Assessment
- Helicobacter Pylori
- Increased Stomach Acid
- Abdominal Pain
- Heartburn (Pyrosis)
- Melena
- Weight Changes
- GI Distress
- Most Commonly in Duodenum
- Duodenal: Pain Relieved by Eating
- Gastric: Pain Caused by Eating
Celecoxib
- Rheumatoid Arthritis
- Osteoarthritis
- Pain
- NSAID
- Selectively Inhibits COX-2
- Sulfa Allergy
- Increased Risk of Thrombosis
- GI Bleed
- Pregnancy > 30 Weeks
Peptic Ulcer Disease Interventions
- Combination Drug Therapy
- Two Antibiotics
- Proton Pump Inhibitor (PPI)
- Decrease Acid Secretion
- Avoid NSAIDs
- Diet and Lifestyle Changes
Sucralfate (Carafate)
- Creates Protective Barrier
- GI Ulcers
- Constipation
- Require Acidic Environment
- Give on Empty Stomach
- Oral Suspension Available
- May Decrease Absorption of Other Meds