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Pharmacology and the Nursing Process, 9th Ed., Lilley, Rainforth Collins & Snyder, 2019
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27 - Antilipemic Drugs

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Pharmacology and the Nursing Process, 9th Ed., Lilley, Rainforth Collins & Snyder, 2019 | Registered Nurse (RN) School Study Aid

27 - Antilipemic Drugs
12 Picmonics to Learn | 18 mins
Cholesterol Lab Values
LDL (Low Density Cholesterol)
< 100 mg/dL
HDL (High Density Cholesterol)
> 40 mg/dL Males
> 50 mg/dL Females
Total Cholesterol
< 200 mg/dL
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1 min
Triglycerides Lab Value
< 150 mg/dL
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51 secs
Statins
Rhabdomyolysis
Hepatotoxicity
HMG-CoA reductase inhibitors
Decrease LDL
Decrease Triglycerides
Increase HDL
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2 mins
Metabolic Syndrome
Assessment
Dyslipidemia
Central Obesity
Insulin Resistance
Hypertension
Increased C-Reactive Protein (CRP)
Increased Fibrinogen
Considerations
Increased Risk Cardiovascular Disease
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1 min
Vitamin B3 - Niacin (Nicotinic Acid)
Mechanism
Decreases Triglycerides
Decreases LDL
Increases HDL
Indications
Dyslipidemia
Pellagra
Diarrhea
Dermatitis
Dementia
Side Effects
Flushing
GI Distress
Hepatotoxicity
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2 mins
Warfarin (Coumadin)
Mechanism of Action
Inhibits Clotting Factors
Indications
Atrial Fibrillation
Venous Thrombosis
Pulmonary Embolism
Assessment
PT/INR Levels
Observe for Bleeding
Contraindications
Pregnancy
Nursing Considerations
Vitamin K and Fresh Frozen Plasma
Prolonged Therapeutic Onset
Maintain Same Diet
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2 mins
Azoles (Ketoconazole)
"-azole" suffix
Indications
Local and Less Serious Systemic Mycosis
Mechanism
Inhibits Ergosterol Synthesis
Inhibits P450
Side Effects
Liver Dysfunction
Inhibition of Testosterone Synthesis
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1 min
Cyclosporine (Sandimmune) Overview
Mechanism
Immunosuppressant
Inhibits Calcineurin, Decreasing IL-2
Indications
Prevent Transplant Rejection
Psoriasis
Rheumatoid Arthritis
Considerations
Monitor Plasma Levels
Avoid Grapefruit Juice
Increased Risk of Lymphoma
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2 mins
Atorvastatin (Lipitor)
Characteristics
-statin Suffix
Mechanism
HMG-CoA Reductase Inhibitors
Indications
High Cholesterol
Side Effects
Hepatotoxicity
Rash
Rhabdomyolysis
Myopathy
Considerations
Monitor Liver Enzymes
Administer at Bedtime
Avoid Grapefruit
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2 mins
Ezetimibe
Indications
Hyperlipidemia
Mechanism of Action
Cholesterol Absorption Blocker
Decreases LDL
Side Effects
Diarrhea
Increased LFT Values
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1 min
Gemfibrozil (Fibrates)
Mechanism of Action
Decreases Triglycerides
Increase in HDL
Slight Decrease in LDL
Indications
Hypertriglyceridemia
Side Effect
Hepatotoxicity
Cholesterol Gallstones
Myopathy
Considerations
Do Not Combine with Statins
Warfarin Toxicity
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2 mins
Liver Enzyme Tests: AST and ALT
AST/ALT Ratio
AST: 8-20 U/L
ALT: 8-20 U/L
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1 min

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