NSAIDs
- Anti-inflammatory
- Analgesic
- Fever
- Closure of Patent Ductus Arteriosus
- Reversible Inhibition of COX-1 and COX-2
- Block Prostaglandin Synthesis
- Interstitial Nephritis
- Gastric Ulcer
- Renal Ischemia
Aspirin (Acetylsalicylic Acid)
- Inhibits Platelet Aggregation
- NSAID
- Thrombotic Event Prevention
- General Pain
- Inflammatory Conditions
- Fever
- Pancytopenia
- GI Ulcers
- Bleeding
- Withhold Before Surgery 7-10 Days
- Reye's Syndrome
Aspirin Poisoning (Salicylism) Assessment
- Nausea and Vomiting
- Tinnitus
- Confusion
- Hyperventilation
- Respiratory Alkalosis
- Metabolic Acidosis
- Coma
- Hyperthermia
Reye's Syndrome
- Aspirin (Salicylates) to Treat Viral Illness (In Children)
- Cerebral Edema
- Lethargy (Decreased LOC)
- Vomiting
- Liver Failure
- Monitor for Increased ICP
- Mannitol (Osmitrol)
- No Aspirin for Children
Ibuprofen (Advil, Motrin)
- NSAID
- COX Inhibitor
- General Pain
- Fever
- Inflammatory Conditions
- GI Ulcers
- Nephrotoxicity
- Rash
- Avoid with Alcohol
- Risk of Thrombotic Event
Prednisone (Glucocorticoids)
- Glucocorticoid
- Inflammatory Conditions
- Organ Transplant Rejection
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Adrenal Insufficiency
- Taper Gradually
Acetaminophen
- Fever
- Pain
- Reversibly Inhibits COX
- Acts Primarily in CNS
- Hepatic Necrosis
- N-acetylcysteine Antidote
Celecoxib
- Rheumatoid Arthritis
- Osteoarthritis
- Pain
- NSAID
- Selectively Inhibits COX-2
- Sulfa Allergy
- Increased Risk of Thrombosis
- GI Bleed
- Pregnancy > 30 Weeks