Immune System Tissues
- Bone Marrow
- B Cells and T Cells Formed
- B Cells Mature
- Thymus
- T Cells Tested For Self-Response
- T Cells Mature
- Lymph Nodes
- Mature B Cells and T Cells Monitor Lymph For Pathogens
- Spleen
- Mature B Cells and T Cells Monitor Blood For Pathogens
Inflammatory Response
- Pathogens Infect Tissue
- Mast Cells Release Histamine
- Histamine Dilates and Increases Capillary Permeability
- Macrophages Engulf Pathogens
- Macrophage Signals Cells With Cytokines
- Responding Neutrophils Cross Capillary Wall
- B And T Lymphocytes Arrive At Injury Site
Hypersensitivity Type I
- Previous Antigen Exposure
- Immediate Reaction
- IgE Cross-linking
- Presensitized Mast Cells
- Histamine Release
- Vasodilation
- Anaphylaxis
- Allergies
- Epinephrine
Anaphylaxis Intervention
- Assess Airway and Oxygen Needs
- Reassure Patient with Anxiety
- Supine Position
- Methylprednisolone (Solu-medrol)
- Epinephrine
- Diphenhydramine (Benadryl)
- Medical Alert Bracelet
Hypersensitivity Type II
- Cytotoxic
- IgM or IgG antibody-mediated
- Membrane Attack Complex (MAC)
- Opsonization
- Complement Activation
- NK Cells
- Direct Coombs test
- Indirect Coombs Test
Hypersensitivity Type III
- Immune Complex
- Antigen-antibody (IgG) complex activates complement
- Neutrophils release lysozomal enzymes
- Arthus Reaction
- Serum Sickness
- Systemic Lupus Erythematosus (SLE)
Hypersensitivity Type IV
- Delayed-Type Hypersensitivity
- T Cell Mediated
- Antibody Independant
- Macrophages Activated
- Transplant Rejection
- PPD Skin Test
- Contact Dermatitis
Transfusion Reactions
- Acute Hemolytic
- Febrile, Non-Hemolytic
- Mild Allergic
- Anaphylactic
- Circulatory Overload
- Sepsis Reaction
- Transfusion-Related Acute Lung Injury (TRALI)
- Massive Blood Transfusion
Stevens-Johnson Syndrome
- Drugs
- < 10% of Body Surface Area (BSA) Involved
- 10-30% BSA Overlaps with Toxic Epidermal Necrolysis (TEN)
- Fever
- Affects Skin and Mucous Membranes
- Bullae Formation
- Necrosis
- Sloughing of Skin
- High Mortality Rate
- Supportive Care
- IVIG (Intravenous Immunoglobulin)
Systemic Lupus Erythematosus (SLE) Mechanism, Treatment and Complications
- Systemic Autoimmune Disease
- 9:1 female to male ratio
- Glucocorticoids
- NSAIDS
- Hydroxychloroquine
- Cyclophosphamide
- Lupus nephritis
- Libman-Sacks Endocarditis
- Secondary Antiphospholipid Antibody Syndrome
- Drug-induced lupus
Systemic Lupus Erythematosus (SLE) Assessment
- Multisystem Inflammatory Disorder
- Malar Rash
- Discoid Rash
- Arrhythmias
- Arthritis
- Hemolytic Anemia
- Seizures
- Glomerulonephritis
- Periods of Exacerbation and Remission
- Diagnosed by ANA (Anti-nuclear antibody assay)
Systemic Lupus Erythematosus (SLE) Diagnosis and Clinical Features
- IM DAMN SHARP acronym
- Immunoglobulins
- Malar rash
- Discoid rash
- Antinuclear antibody
- Mucositis
- Neurologic disorders
- Serositis
- Hematologic disorders
- Arthritis
- Renal disorders
- Photosensitivity
Atopic Dermatitis / Eczema
- Pruritic Vesicles
- Inflammatory Skin Rash
- Cheeks in Children
- Skin Flexural Areas
- Associated with Asthma and Allergic Rhinitis
- Tacrolimus
- Moisturizers
- Corticosteroids
- Phototherapy
- Avoid Triggers
- Antihistamines
Meningitis Assessment
- Nausea and Vomiting
- Fever
- Nuchal Rigidity
- Severe Headache
- Purpura
- Seizures
- Photophobia
- Opisthotonus Position
- High-Pitched Cry
- Bulging Fontanel
Sarcoidosis Symptoms
- Black Females
- Asymptomatic
- Uveitis
- Interstitial Fibrosis
- Erythema Nodosum
- Hepatomegaly
- Myocardial Sarcoidosis
- Lupus Pernio
Myasthenia Gravis
- Antibodies to Acetylcholine Receptor
- Ptosis
- Diplopia
- Weakness with Muscle Use
- Respiratory Death
- Thymus Associated
- Acetylcholinesterase Inhibitors
- Plasmapheresis
- Thymectomy