Vitamin A (Retinol)
- Maintains Mucous Membranes
- Eyes and Skin
- Dietary Deficiency
- Skin Disorders
- Hepatosplenomegaly
- Jaundice
- Increased ICP
- Vomiting
- Teratogen
- Animal Food Products
- Dark Green and Orange Fruits/Vegetables
Vitamin A (Retinol) Function and Deficiency
- Retinol
- Constituent of Visual Pigments
- Differentiation of Epithelial Cells into Specialized Tissue
- Night Blindness
- Dry Skin
- Used to Treat Measles
- Antioxidant
Vitamin A (Retinol) Toxicity
- Alopecia
- Vision Changes
- Headache
- Skin Changes
- Hyperlipidemia
- Hepatotoxicity
- Arthralgias
- Teratogen
- Cleft palate
- Cardiac Abnormalities
Vitamin B1 (Thiamine)
- Branched-chain Ketoacid Dehydrogenase
- Pyruvate Dehydrogenase
- Alpha-ketoglutarate Dehydrogenase
- Transketolase
- Wernicke-Korsakoff Syndrome
- Beriberi
- ATP Depletion
- Aerobic Tissues Like Brain and Heart Affected First
- Deficiency Can Worsen with Glucose Infusion
Vitamin B1 (Thiamine)
- Carbohydrate Metabolism
- Dietary Deficiency
- Beriberi
- Wernicke-Korsakoff
- Alcoholics Highest Risk
- Give Before Glucose
- Give IM or IV
- Enriched Whole Grains
- Pork
Vitamin B12 (Cobalamin) Deficiency Causes
- Vegans
- Pernicious Anemia
- Gastric Bypass Surgery
- Malabsorption
- Sprue
- Enteritis
- Crohn's Disease
- Diphyllobothrium latum
Vitamin B12 (Cobalamin) Mechanism and Deficiency
- Cobalamin
- Large reserve pool in the liver
- Homocysteine to methionine
- Methylmalonyl CoA to succinyl CoA
- Macrocytic Megaloblastic Anemia
- Hypersegmented Neutrophils
- Neurologic defects
- Posterior column
- Lateral corticospinal tract
- Spinocerebellar tract
Vitamin B3 (Niacin)
- Derived from Tryptophan
- Synthesis Requires Vitamin B6
- Constituent of NAD+
- Hartnup Disease
- Carcinoid Syndrome
- Pellagra
- Diarrhea
- Dermatitis
- Dementia
- Glossitis
- Flushing
Vitamin B3 - Niacin (Nicotinic Acid)
- Decreases Triglycerides
- Decreases LDL
- Increases HDL
- Dyslipidemia
- Pellagra
- Diarrhea
- Dermatitis
- Dementia
- Flushing
- GI Distress
- Hepatotoxicity
Vitamin B5 (Pantothenate)
- Pantothenate
- Pyruvate Dehydrogenase
- Coenzyme A
- Fatty Acid Synthase
- Enteritis
- Dermatitis
- Alopecia
- Adrenal Insufficiency
Vitamin B6 (Pyridoxine)
- Pyridoxal Phosphate
- Transamination
- Decarboxylation
- Glycogen Phosphorylase
- Cystathionine Synthase
- Heme Synthesis
- Niacin Synthesis
- Neurotransmitter Synthesis
Vitamin B6 (Pyridoxine)
- Amino Acid and Protein Metabolism
- Heme Synthesis
- Neurotransmitters
- Adjunct to Isoniazid
- Dietary Deficiency
- Premenstrual Syndrome (PMS)
- Ataxia
- Peripheral Neuropathy
- Levodopa
- Cereals and Meats
Vitamin B6 (Pyridoxine) Deficiency
- Deficiency From Isoniazid
- Deficiency From Oral Contraceptives
- Seizures
- Hyperirritability
- Peripheral Neuropathy
- Sideroblastic Anemia
Vitamin C (Ascorbic Acid)
- Antioxidant
- Collagen Formation
- Steroid Synthesis
- Dietary Deficiency
- Scurvy
- GI Distress
- Citrus Fruits
- May Improve Healing
Vitamin C Mechanism and Deficiency
- Ascorbic acid
- Antioxidant
- Protects Against Free Radicals
- Keeps Iron in Reduced State
- Hydroxylation of Proline and Lysine
- Necessary for Dopamine B Hydroxylase
- Scurvy
- Swollen Gums
- Bruising
- Poor Wound Healing
- Hemarthrosis
- Perifollicular Hemorrhages
- Anemia
Vitamin D Deficiency
- Rickets in children
- Bending bones
- Rachitic rosary
- Breast milk has decreased vitamin D
- Osteomalacia in adults
- Tetany from Hypocalcemia
Vitamin D Metabolism/Mechanism
- Ergocalciferol (Vitamin D2)
- Plant Sources
- Cholecalciferol (Vitamin D3)
- Sunlight Conversion in Skin
- 7-Dehydrocholesterol
- Liver Hydroxylation
- 25-(OH) D (25-hydroxyvitamin D)
- Storage Form
- Kidney Hydroxylation
- 1,25-(OH)2 D (1,25-dihydroxyvitamin D)
- Active Form Calcitriol
- Absorbs Calcium and Phosphorus in Intestine
Vitamin D Toxicity
- Kidney Stones
- Metastatic Calcification of the Kidney
- Loss of Appetite
- Abdominal Pain
- Sarcoidosis
Vitamin E (Alpha-tocopherol)
- Antioxidant
- Fat Malabsorption Syndrome
- Alpha-TTP Deficiency
- Bleeding
- Increased Risk Hemorrhagic Stroke
- Limit Doses < 200 IU per Day
- Nuts and Whole Grains
- Vegetable Oils
Vitamin E Deficiency
- Antioxidant
- Protects Erythrocytes
- Protects from Free Radical Damage
- Hemolytic Anemia
- Posterior Column
- Spinocerebellar Tract
Vitamin K
- Dark Green Leafy Vegetables
- Synthesized by Intestinal Flora
- Activated by Epoxide Reductase
- Gamma Carboxylation of Glutamate
- Activation of Clotting Factors II, VII, IX, X, Protein C and S
- Deficiency with Broad Spectrum Antibiotics
- Neonatal Hemorrhage with Increased PT and aPTT
- Warfarin is a Vitamin K Antagonist
Vitamin K1 (Phytonadione)
- Synthesizes Clotting Factors II, VII, IX, X
- Hypoprothrombinemia
- Newborn Prophylaxis
- Bleeding from Warfarin Overdose
- Shock
- Kernicterus
- Cardiac Arrest
- Bile Salts required for Intestinal Absorption
- Increased Risks with IV Administration
Cholecalciferol (Vitamin D3)
- Vitamin D3
- Dietary Supplement
- Vitamin D Deficiency
- Fatigue
- Constipation
- Hypercalcemia
- Kidney Stones
- More Effective Than Ergocalciferol
- Hypervitaminosis D
Cobalamin (Vitamin B12)
- Vitamin B12
- Vitamin Deficiency
- Pernicious Anemia
- Hypokalemia
- Arthralgia
- Dizziness
- IM Injection for Pernicious Anemia
- Never Give IV
Ergocalciferol (Vitamin D2)
- Vitamin D2
- Hypoparathyroidism
- Rickets
- Hypophosphatemia
- Fatigue
- Constipation
- Hypercalcemia
- Kidney Stones
Niacin Therapy (Vitamin B3)
- Inhibits Lipolysis in Adipose Tissue
- Reduces Hepatic VLDL Secretion
- Decrease Triglycerides
- Decrease LDL
- Increase HDL
- Flushing
- Decreased by Aspirin
- Hyperglycemia
- Hyperuricemia
Riboflavin (Vitamin B2)
- Vitamin B2
- FAD
- FAD Makes 1.5 ATP
- Succinate to Fumarate
- Glossitis
- Cheilosis
- Corneal Vascularization