Gout Treatment
- NSAIDs
- Glucocorticoids
- Colchicine
- Impairs Leukocyte Chemotaxis
- Inhibit Xanthine Oxidase
- Allopurinol
- Febuxostat
- Inhibit Reabsorption of Uric Acid
- Probenecid
Prednisone (Glucocorticoids)
- Glucocorticoid
- Inflammatory Conditions
- Organ Transplant Rejection
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Adrenal Insufficiency
- Taper Gradually
NSAIDs
- Anti-inflammatory
- Analgesic
- Fever
- Closure of Patent Ductus Arteriosus
- Reversible Inhibition of COX-1 and COX-2
- Block Prostaglandin Synthesis
- Interstitial Nephritis
- Gastric Ulcer
- Renal Ischemia
TNF-Alpha Inhibitors Overview
- Downregulates Pro-inflammatory Cytokines
- Decreased Lymphocyte Activation and Migration
- Granuloma Breakdown
- Crohn's Disease
- Rheumatoid Arthritis
- Juvenile Rheumatoid Arthritis
- Psoriasis
- Ankylosing Spondylitis
TNF-Alpha Inhibitor Drugs and Complications
- Etanercept
- Decoy TNF- Alpha receptor
- Anti-TNF- Alpha antibody
- Adalimumab
- Infliximab
- Increased risk of infection
- Predispose to Tuberculosis (TB) reactivation
- Order Baseline PPD- skin test
- Quantiferon Gold In-Tube
- Order Chest X-Ray
Pegloticase
- Recombinant Uricase
- Converts Uric Acid to Allantoin
- 3rd Line Agent
- Chronic Gout
- Infusion Reactions
- Contraindicated in G6PD Deficiency
- Gout Flares