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First Aid for the USMLE Step 1 (2020)
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First Aid for the USMLE Step 1 (2020) | Physician Assistant (PA) School Study Aid

Page 487 -
6 Picmonics to Learn | 9 mins
Gout Treatment
Acute (Acute-angle)
NSAIDs
Glucocorticoids
Colchicine
Impairs Leukocyte Chemotaxis
Chronic Gout (Crone Goat)
Inhibit Xanthine Oxidase
Allopurinol
Febuxostat
Inhibit Reabsorption of Uric Acid
Probenecid
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1 min
Prednisone (Glucocorticoids)
Mechanism
Glucocorticoid
Indications
Inflammatory Conditions
Organ Transplant Rejection
Side Effects
Cataracts and Glaucoma
Cushing's Syndrome
Osteoporosis
Immunosuppression
Hyperglycemia
Ulcers
Considerations
Adrenal Insufficiency
Taper Gradually
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2 mins
NSAIDs
Indications
Anti-inflammatory
Analgesic
Fever
Closure of Patent Ductus Arteriosus
Mechanism of Action
Reversible Inhibition of COX-1 and COX-2
Block Prostaglandin Synthesis
Side Effects
Interstitial Nephritis
Gastric Ulcer
Renal Ischemia
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1 min
TNF-Alpha Inhibitors Overview
Mechanism
Downregulates Pro-inflammatory Cytokines
Decreased Lymphocyte Activation and Migration
Granuloma Breakdown
Treats
Crohn's Disease
Rheumatoid Arthritis
Juvenile Rheumatoid Arthritis
Psoriasis
Ankylosing Spondylitis
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1 min
TNF-Alpha Inhibitor Drugs and Complications
Etanercept
Decoy TNF- Alpha receptor
Anti-TNF- Alpha antibody
Adalimumab
Infliximab
Complications
Increased risk of infection
Predispose to Tuberculosis (TB) reactivation
Order Baseline PPD- skin test
Quantiferon Gold In-Tube
Order Chest X-Ray
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2 mins
Pegloticase
Characteristics
Recombinant Uricase
Converts Uric Acid to Allantoin
3rd Line Agent
Indications
Chronic Gout
Considerations
Infusion Reactions
Contraindicated in G6PD Deficiency
Gout Flares
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2 mins

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