Human Immunodeficiency Virus (HIV) Interventions
- Adequate Nutrition
- Small Frequent Meals
- IV Hydration
- Emotional Support
- HAART
- Transmission Education
- Strict Asepsis for Invasive Procedures
- Treat Opportunistic Infections
HAART
- HIV
- Begin at Diagnosis
- 3 Drugs
- 2 NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor)
- or Protease Inhibitor
- or Integrase Inhibitor
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- HIV
- Pregnancy and Prophylaxis given ZDV
- Inhibit Nucleotide Binding to Reverse Transcriptase
- Chain Termination
- Require Phosphorylation
NRTIs for HIV (Drug Names)
- DEALSZ
- Didanosine (DDI)
- Emtricitabine (FTC)
- Abacavir (ABC)
- Lamivudine (3TC)
- Stavudine (d4T)
- Zidovudine (ZDV)
- Tenofovir (TDF)
NRTI Toxicity
- Bone Marrow Suppression
- Reverse with G-CSF and Erythropoietin
- Rash
- Neuropathy
- Anemia
- Pancreatitis
- Lactic Acidosis
NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitors)
- HIV
- Do Not Require Intracellular Metabolism
- Inhibits Reverse Transcriptase
- Rash
- Hepatotoxicity
- Vivid Dreams and CNS Symptoms
- Pregnancy
NNRTI Drug Names
- Nevirapine (Viramune)
- Rilpivirine (Edurant)
- Delavirdine (DLV, Rescriptor)
- Efavirenz (EFV, Sustiva)
- Etravirine (ETR, Intelence)
Integrase Inhibitors
- -gravir Suffix
- HIV
- Blocks Insertion of Viral Genome
- Inhibit Actions of Integrase
- Hypercholesterolemia
- Increased LFT's
- Insomnia
- Increased Creatine Kinase (CK)
Protease Inhibitors
- End in "-navir"
- HIV/AIDS
- Hepatitis C
- Inhibit Protease
- Unable to Cleave Proteins
- Inhibits Maturation of New Virus
- GI Distress
- Nephropathy
- Lipodystrophy
- Hyperglycemia
Fusion Inhibitors
- HIV
- Maraviroc
- Binds CCR-5 on T Cells
- Blocks Interaction with gp120
- Enfuvirtide
- Binds gp41
- Inhibits Viral Entry
- Skin Reactions at Injection Sites (Enfuvirtide)