Polymyositis / Dermatomyositis Disease
- Idiopathic Inflammatory Myopathy
- More Common in Women
- Endomysial Inflammation with CD8+ Cells (Polymyositis)
- Perimysial Inflammation with CD4+ Cells (Dermatomyositis)
- Symmetric Proximal Muscle Weakness
- Dysphagia
- Lung and Cardiac Involvement
- Malar Rash
- Shawl-like Shoulder Rash
- Gottron Papules on Knuckles
- Heliotrope Rash
Acanthosis Nigricans
- Endocrine Disorders
- Diabetes Mellitus
- Obesity
- Malignancy
- Velvety Plaques
- Dark, Thickened Flexural Areas
- Hyperkeratosis with Melanocytes
- Treat Underlying Disorder
Stomach Cancer
- Adenocarcinoma
- Intestinal Type
- Smoked Foods Containing Nitrosamines
- Achlorhydria
- Type A Blood
- Helicobacter pylori
- Diffuse Type
- Signet Ring Cells
- Linitis Plastica (Leather Bottle Stomach)
- Acanthosis Nigricans
- Left Supraclavicular Lymph Node
- Virchow's Node
- Subcutaneous Periumbilical Mets
- Sister Mary Joseph's Nodule
- Bilateral mets to ovaries
- Krukenberg's tumor
Adenocarcinoma of the Lung
- Most Common Lung Cancer
- Most Common in Nonsmokers
- Peripheral Location
- KRAS, EGFR, and ALK Mutations
- Glandular Pattern
- Often Stains with Mucin
- Presents with Hemoptysis
- Clubbing
- Surgical Resection
- Chemotherapy and Radiation
Hypercalcemia
- > 10.5 mg/dL Ca2+
- Pathologic Fractures
- Lethargy
- Hypercoagulation
- Constipation
- ECG Changes
- QT Shortening
- No Calcium Intake
- Chelating Drugs
- Calcitonin
- Bisphosphonates
- Loop Diuretics instead of Thiazide Diuretics
- Increased Risk for Renal Calculi
- Increase Fluids
Hypercalcemia Causes
- Two CHIMPANZEES Acronym
- Thyroid Disorders
- Calcium Supplements
- Hyperparathyroidism
- Iatrogenic (Drugs, immobility)
- Milk-Alkali Syndrome
- Paget's Disease of Bone
- Acromegaly or Addison's Disease
- Neoplasms
- Zollinger-Ellison Syndrome
- Excessive Vitamin A
- Excessive Vitamin D
- Sarcoidosis
Cushing's Syndrome Characteristics
- More Common in Women
- Glucocorticoids
- Decreased ACTH
- Primary Adrenal Disease
- Increased ACTH
- Pituitary Adenoma (Cushing's Disease)
- Paraneoplastic: Small Cell Carcinoma
- CRF-releasing Tumors
Syndrome Of Inappropriate Antidiuretic Hormone (SIADH)
- Hypersecretion of ADH
- Increased Sensitivity to ADH
- Serum Hypoosmolality
- Coma and Seizure
- Dilutional Hyponatremia
- Cramps and Tremors
- Euvolemia
- Change in LOC
Polycythemia Vera Disease
- JAK2 Mutation leading to increased red blood cells
- Tyrosine Kinase
- Erythromelalgia
- Pruritus
- Often After Hot Shower
- Headache
- Phlebotomy
- Aspirin
Pancreatic Adenocarcinoma Symptoms and Risk Factors
- Abdominal Pain
- Anorexia and Weight Loss
- Migratory Superficial Thrombophlebitis
- New-Onset Diabetes
- Jaundice
- Steatorrhea
- White Stool
- Palpable but Non-tender Gall Bladder
- Elderly
- Chronic Pancreatitis
- Smoking
- Alcoholism
- Diabetes
Teratoma
- Germ-cell Tumor
- Dermoid Cyst (Benign and Mature Teratoma)
- Immature Teratoma (Malignant)
- Struma Ovarii
Neuroblastoma Characteristics and Presentation
- Malignant Neuroendocrine Tumor
- Neural Crest Cells Origin
- Sympathetic Ganglia
- Adrenal Glands
- Amplification of N-myc Oncogene
- Most Common Cancer In Infancy
- Abdominal Mass That Can Cross Midline
- Gastrointestinal Distress
- Metastasis
- Raccoon Eyes
- Opsoclonus-Myoclonus Syndrome
Neuroblastoma Diagnosis and Management
- 24-hour Urine Test
- Increased Catecholamines
- Increased Homovanillic and Vanillylmandelic Acid
- Ultrasound
- Magnetic Resonance Imaging (MRI)
- Biopsy
- Small Round Blue Cells
- Homer-Wright Rosettes
- Bombesin Positive
- Neuron Specific Enolase Positive
- Local Excision
- Chemotherapy
- Radiation
Small Cell (Oat Cell) Carcinoma
- Aggressively Malignant
- Strong Correlation with Smoking
- Central Location
- Amplification of Myc Oncogenes
- Narrowing of Bronchial Airways
- Cushing's Syndrome
- Ectopic ACTH
- Syndrome Of Inappropriate Antidiuretic Hormone (SIADH)
- Lambert-Eaton Syndrome
- Kulchitsky Cells
- Neuron-Specific Enolase Positive
- Chromogranin A Positive
- Chemotherapy and Radiation
Lambert-Eaton Syndrome
- Autoantibody to the Presynaptic Calcium Channel on Motor Neurons
- Inhibits Acetylcholine (ACh) Release at Neuromuscular Junction
- Paraneoplastic Syndrome
- Small Cell Lung Cancer
- Proximal Muscle Weakness
- Improves with Muscle Use
- Autonomic Symptoms
- Extraocular Muscle Sparing
Myasthenia Gravis
- Antibodies to Acetylcholine Receptor
- Ptosis
- Diplopia
- Weakness with Muscle Use
- Respiratory Death
- Thymus Associated
- Acetylcholinesterase Inhibitors
- Plasmapheresis
- Thymectomy