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First Aid for the USMLE Step 1 (2021) | Physician Assistant (PA) School Study Aid
Acetaminophen
- Indications
- Fever
- Pain
- Mechanism of Action
- Reversibly Inhibits COX
- Acts Primarily in CNS
- Side Effect
- Hepatic Necrosis
- N-acetylcysteine Antidote
51 secs
Acetaminophen Antidote
- Antidote
- N-Acetylcysteine
33 secs
Acetylcholinesterase Inhibitor Poisoning
- DUMBBELSS
- Diarrhea
- Urination
- Miosis
- Bronchospasm
- Bradycardia
- Emesis
- Lacrimation
- Salivation
- Sweating
2 mins
Acetylcholinesterase Inhibitor Antidote
- Antidote
- Atropine
- Pralidoxime
1 min
Atropine
- Indications
- Blocks DUMBBeLSS
- Bradycardia
- Side Effects
- Skin Flushing
- Increased Temperature
- Dry Mouth
- Cycloplegia
- Disorientation
- Mydriasis
1 min
Antimuscarinic Antidote
- Antidote
- Physostigmine Salicylate
44 secs
Arsenic, Gold and Copper Antidotes
- Toxic Metals
- Arsenic
- Gold
- Copper
- Antidotes
- Penicillamine
- Dimercaprol (BAL)
- Succimer
2 mins
Benzodiazepines Overview
- Indications
- First Line for Status Epilepticus
- Anesthesia Induction
- Anxiety
- Eclampsia
- Detoxification
- Mechanism of Action
- '-zepam' and '-zolam" Suffix
- Increase Frequency of Cl- Channel Opening
- Side Effects
- Decrease REM Sleep
- CNS Depression
- Dependence
- Antidote
- Flumazenil for Overdose
2 mins
Benzodiazepine Antidote
- Antidote
- Flumazenil
40 secs
Systemic Effects of Beta-Blockers
- Respiratory
- Bronchoconstriction
- Metabolic
- Decreased Insulin
- Decreased Glycolysis and Lipolysis
- Eye
- Reduces Intraocular Pressure
1 min
Cyanide Poisoning: Pathophysiology and Clinical Manifestation
- Pathophysiology
- Inhibits Complex IV of Oxidative Phosphorylation
- Forces Cells Into Anaerobic Metabolism
- Presentation
- Exposure to Fire Fumes
- Industrial Exposure
- Headache and Confusion
- Arrhythmias
- "Cherry Red" Skin
- Almond Breath/Taste
- Acute Renal Failure
4 mins
Cyanide Poisoning Diagnosis and Treatment
- Lab Findings
- Lactic Acidosis
- Elevated Venous PO2
- Check Carboxyhemoglobin
- Management
- Sodium Nitrate PLUS Sodium Thiosulfate
- Methemoglobinemia
- OR Hydroxocobalamin (First Line)
4 mins
Acute Digoxin Toxicity
- Clinical Symptoms
- Hyperkalemia
- Cholinergic (Nausea, Vomiting, Diarrhea)
- Blurry Yellow Green Vision with Halo of Light
- Arrhythmia
- Bradycardia
- EKG Changes
- Prolonged PR interval
- Decreased QT
- Scooping on EKG
- T Wave Inversion
2 mins
Digoxin Toxicity Treatment
- Activated Charcoal
- Slowly Normalize K+
- Digibind (Anti-Digoxin Fab)
- Magnesium Sulfate
- Lidocaine
- Cardiac Pacing
2 mins
Factor Xa Inhibitors
- Characteristics
- Inhibit Factor Xa
- -xaban
- Drugs
- Apixaban
- Rivaroxaban
- Indications
- Pulmonary Embolism
- Nonvalvular Atrial Fibrillation
- Deep Vein Thrombosis
- Considerations
- Andexanet Alfa
2 mins
Heparin Mechanisms
- Mechanism of Action
- Short Half-life
- Antithrombin Activation Cofactor
- Decrease Thrombin, Factor Xa
- Side Effects
- Bleeding
- Heparin Induced Thrombocytopenia (HIT)
- Antidote
- Protamine Sulfate
2 mins
Enoxaparin (Lovenox)
- Mechanism of Action
- Inhibits Clotting Factors
- Factor Xa
- Indications
- Clot Formation Prevention
- Side Effects
- Heparin Induced Thrombocytopenia (HIT)
- Bleeding
- Considerations
- Medication Education
- Subcutaneous Injection
- 2 Inches from Umbilicus or Incisions
- Antidote
- Protamine Sulfate
2 mins
Iron (Ferrous Sulfate)
- Mechanism
- Ferrous Salts
- Indications
- Anemia
- Side Effects
- GI Distress
- Nausea and Vomiting
- Dark Stools
- Considerations
- Take Between Meals
- Liquid can Stain Teeth
- Keep out of Reach from Children
- Caution with GI Disorders
- Avoid Antacids
3 mins
Iron Antidote
- Antidote
- DeFEroxamine
23 secs
Lead Antidotes
- Antidotes
- Dimercaprol
- CaEDTA
- Succimer
39 secs
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Opioids Overview
- Indications
- Pain
- Weaning
- Cough
- Diarrhea
- Mechanism of Action
- Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
- Decrease Synaptic Transmission
- Side Effects
- Respiratory Depression
- Addiction
- Miosis
- Constipation
2 mins
Opioid Antidote
- Antidote
- Naloxone
29 secs
Aspirin Poisoning (Salicylism) Assessment
- Early Symptoms
- Nausea and Vomiting
- Tinnitus
- Confusion
- Hyperventilation
- Respiratory Alkalosis
- Late Symptoms
- Metabolic Acidosis
- Coma
- Hyperthermia
1 min
Tricyclic Antidepressants (TCAs) Overview
- Mechanism of Action
- Blocks Serotonin and NE Reuptake
- Lipid-soluble
- Side Effects
- Adverse CNS Effects
- Anticholinergic
- Antihistamine
- Tri-C: Convulsion, Coma, Cardiotoxicity
- Blocks Alpha1 Receptors
2 mins
Tricyclic Antidepressant (TCA) Antidote
- Antidote
- Sodium Bicarbonate (NaHCO3)
27 secs
Warfarin
- Mechanism of Action
- Interferes with Vitamin K-dependent Clotting Factors
- Extrinsic Pathway
- Bridge with Heparin
- Indications
- Chronic Anticoagulation
- Side Effects
- Bleeding
- Necrosis
- Cytochrome P450
- Contraindications
- Pregnancy
- Antidote
- FFP + Vitamin K
2 mins
Warfarin Antidotes
- Antidotes
- Vitamin K
- Fresh Frozen Plasma
59 secs
Vancomycin Side Effects & Toxicity
- Side Effects
- Thrombophlebitis
- Nephrotoxicity
- Ototoxicity
- Diffuse Flushing Called Red Man Syndrome
- Prevent with Antihistamine
- Prevent with Slow Infusion
2 mins
Dilated Cardiomyopathy
- Chronic Alcohol Abuse
- Doxorubicin Toxicity
- Cocaine Use
- Wet Beriberi
- Hemochromatosis
- Coxsackie B
- Chagas Disease
- Peripartum
- S3
- Eccentric Hypertrophy
2 mins
Torsades de Pointes
- Characteristics
- Polymorphic Ventricular Tachycardia
- Prolonged QT Interval
- QRS Twist Around Isoelectric Line
- Causes
- Congenital
- Antibiotics
- Antiarrhythmics
- Antipsychotics
- Antidepressants
- Electrolyte Deficiencies
- Complications
- Ventricular Fibrillation
- Treatment
- Stable: Magnesium Sulfate
- Unstable: Defibrillation
3 mins
Amphetamines Intoxication Assessment
- Euphoria
- Insomnia
- Mydriasis
- Diaphoresis
- Hypertension
- Tachycardia
- Paranoia
- Anxiety
- Anorexia
- Seizures
2 mins
Amphetamine Antidote
- Antidote
- Ammonium Chloride (NH4Cl)
- Acidify Urine
34 secs
Sumatriptan
- Mechanism of Action
- Short Half-Life
- 5-HT Agonist
- Inhibits Trigeminal Nerve Activation
- Induces Vasoconstriction
- Indications
- Migraine
- Cluster Headache
- Side Effects
- Increased Risk of Serotonin Syndrome
- Paresthesias
- Coronary Vasospasm
- Contraindication
- Prinzmetal's Angina
- Coronary Artery Disease (CAD)
3 mins
Methylergonovine (Methergine) and Ergotamine (Ergot Alkaloids)
- Mechanism
- Smooth Muscle Contraction
- Vasoconstriction
- Indications
- Migraine
- Postpartum Hemorrhage
- Side Effects
- Nausea and Vomiting
- Severe Hypertension
- Tachycardia
- Considerations
- 2nd Line Agent
2 mins
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