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First Aid for the USMLE Step 1 (2021)
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First Aid for the USMLE Step 1 (2021) | Physician Assistant (PA) School Study Aid

Page 424 -
5 Picmonics to Learn | 11 mins
Abetalipoproteinemia
Pathophysiology
Autosomal Recessive
Deficiency of Apolipoproteins B-48 and B-100
MTTP Gene Mutation
Clinical Features
Malabsorption
Steatorrhea
Failure to Thrive
Ataxia
Retinitis Pigmentosa
Spinocerebellar Degeneration
Diagnosis
Lipid-Laden Enterocytes
Acanthocytes
Decreased Cholesterol and LDL
Treatment
Vitamin E (Alpha-Tocopherol)
picmonic thumbnail
4 mins
Pyruvate Kinase Deficiency
Pathophysiology
Autosomal Recessive
Defect in Pyruvate Kinase
Decreased ATP
Extravascular Hemolysis
Presentation / Symptoms
Hemolytic Anemia in a Newborn
Diagnosis
RBC Enzyme Assay
Echinocytes
Burr Cells
Small Uniform Projections
Normocytic Anemia
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2 mins
Primary Myelofibrosis
Characteristics
Bone Marrow Fibrosis
Extramedullary Hematopoiesis
JAK2 Kinase Mutation
Symptoms
Fatigue
Weight Loss
Splenomegaly
DIagnosis
Pancytopenia
Dacrocytes (Teardrop Cells)
Dry Tap on Bone Marrow Aspiration
Treatment
Stem Cell Transplantation
Transfusion
Ruxolitinib (JAK2 Inhibitor)
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2 mins
Hemolytic Uremic Syndrome (HUS)
Children
Pathophysiology
Preceded by Acute Diarrheal Illness
Endothelial Damage
Classic Triad of Symptoms
Microangiopathic Hemolytic Anemia (MAHA)
Thrombocytopenia
Renal Failure
Labs
Helmet cells
LDH
Treatment
Dialysis
Supportive
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2 mins
G6PD Deficiency
X-linked Recessive
Hemolytic Anemia
Inflammatory Response
Fava Beans
Sulfonamides
Primaquine
Anti TB Drugs
Heinz Bodies
Bite Cells
Prevalent Among African Americans due to Increased Malarial Resistance
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2 mins

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