Normocytic Hemolytic Anemia Causes
- Hereditary Spherocytosis
- RBC Enzyme Deficiency
- Hemoglobin C Defect
- Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Sickle Cell Anemia
- Autoimmune
- Microangiopathic
- Mechanical Destruction
- Prosthetic Cardiac Valves
- Infection
- Snake Venom
Hereditary Spherocytosis Disease
- Northern Europeans
- Autosomal Dominant
- Spectrin/Ankyrin Deficiency
- Spherocyte Formation
- Hemolytic Anemia
- Bilirubin Gallstones
- Jaundice
- Splenomegaly
Hereditary Spherocytosis Diagnosis & Treatment
- Increased MCHC
- Spherocytes
- Normocytic Anemia
- Eosin-5-Maleimide (EMA) Binding Test
- Osmotic Fragility Test
- Glycerol Lysis Test
- Folic Acid
- Splenectomy
G6PD Deficiency
- X-linked Recessive
- Hemolytic Anemia
- Inflammatory Response
- Fava Beans
- Sulfonamides
- Primaquine
- Anti TB Drugs
- Heinz Bodies
- Bite Cells
- Prevalent Among African Americans due to Increased Malarial Resistance
G6PD Mechanism
- Turns NADP+ to NADPH
- NADPH Used by Glutathione Reductase
- Detoxifies Free Radicals and Peroxides
- X-linked Recessive
Pyruvate Kinase Deficiency
- Autosomal Recessive
- Defect in Pyruvate Kinase
- Decreased ATP
- Extravascular Hemolysis
- Hemolytic Anemia in a Newborn
- RBC Enzyme Assay
- Echinocytes
- Burr Cells
- Small Uniform Projections
- Normocytic Anemia
Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Defective PIG-A Gene
- Deficiency of DAF (Decay Accelerating Factor CD55)
- Dark Urine in the Morning
- Intravascular Hemolysis
- Thrombosis
- Decreased CD55 and CD59
- RBC Transfusion
- Eculizumab
- Bone Marrow Transplant is Curative
Sickle Cell Anemia (Mechanism)
- Intrinsic Normocytic Hemolytic Anemia
- Point Mutation
- Autosomal Recessive
- African American
- Dehydration or Decreased O2
- Newborns Asymptomatic
- Heterozygote Malarial Resistance
Sickle Cell Anemia (Signs and Complications)
- Crew-cut on Skull X-ray
- Auto-splenectomy
- Painful Crisis
- Aplastic Crisis
- Splenic-sequestration Crisis
- Hyper-hemolytic Syndrome
- Renal Papillary Necrosis
- Salmonella osteomyelitis
- Pulmonary Hypertension
- Hyposthenuria
Sickle Cell Anemia (Management)
- Hydroxyurea
- Bone Marrow Transplant
- Folate
- Exchange Transfusion
- Penicillin Prophylaxis