Cephalosporins Overview
- Beta lactam drug
- Inhibits cell wall synthesis
- Bactericidal
- Hypersensitivity reactions
- Vitamin K Deficiency
- Disulfiram like reaction with Alcohol
- Increased Nephrotoxicity of Aminoglycosides
1st Generation Cephalosporin
- Cefazolin
- Cephalexin
- Proteus mirabilis
- E. coli
- Klebsiella
- Gram-Positive Cocci
2nd Generation Cephalosporin
- Cefoxitin
- Cefaclor
- Cefuroxime
- Proteus mirabilis
- E. coli
- Klebsiella
- Gram-Positive Cocci
- Haemophilus influenzae
- Enterobacter
- Neisseria
- Serratia marcescens
3rd Generation Cephalosporin
- Cefotaxime
- Ceftriaxone
- Cefdinir
- Ceftazidime
- Pseudomonas
- Serious Gram-Negative Bacteria Resistant to Other Beta-Lactams
4th Generation Cephalosporin
- Cefepime
- Increased Activity Against Gram-Positive Infections and Pseudomonas
5th Generation Cephalosporin
- Beta-Lactam
- Resistant Bacteria
- Broad Spectrum Gram-Positive and Gram-Negative
- Ceftobiprole
- Has Pseudomonas Coverage
- Ceftaroline
- No Pseudomonas Coverage
Beta-Lactamase Inhibitors
- Often Combined with Penicillin Antibiotics
- Clavulanic Acid
- Sulbactam
- Tazobactam