Antipsychotics Overview
- Typical
- Atypical
- Blocks D2 Receptor
- 2nd Generation Blocks the 5-HT 2 Receptor
- Psychosis
- Delirium
- Bipolar Disorder
- Tourette’s Syndrome
- Hyperprolactinemia
- Extrapyramidal Symptoms
- Tardive Dyskinesia
- Neuroleptic Malignant Syndrome
Chlorpromazine (Thorazine)
- Low Potency Antipsychotic
- Schizophrenia
- Hiccups
- Sedation
- Weight Gain
- Orthostatic Hypotension
- Anticholinergic Effects
- QT Prolongation
- Neuroendocrine Effects
- Caution in Seizure Patients
- Corneal Deposits
Promethazine (Phenergan)
- Histamine H1 Receptor Antagonist
- Weak Dopamine Antagonist
- Nausea and Vomiting
- Motion Sickness
- Respiratory Depression
- Sedation
- Anticholinergic Effects
- Extrapyramidal Symptoms
- Use Large Bore IV
- Monitor for Tissue Necrosis
Haloperidol (Haldol)
- High Potency Antipsychotic
- Migraine
- Schizophrenia
- Extrapyramidal Symptoms
- Weight Gain
- QT Prolongation
- Restlessness
- Caution in Seizure Patients
- Neuroleptic Malignant Syndrome
High Potency Antipsychotic Drugs
- Fluphenazine
- Trifluoperazine
- Haloperidol
- Pimozide
- Extrapyramidal Symptoms
- Short Term
- Dystonia
- Restlessness (Akathisia)
- Torticollis
- Long Term
- Tardive Dyskinesia
- Parkinson's-Like Symptoms
- Neuroleptic Malignant Syndrome
Low Potency Antipsychotic Drugs
- Chlorpromazine
- Corneal Deposits
- Thioridazine
- Retinal Deposits
- Alpha1 Antagonist Effects
- Anticholinergic Effects
- Antihistamine Effects
Atypical Antipsychotics
- Schizophrenia
- Unknown Mechanism
- Seizures
- Prolonged QT Interval
- Agranulocytosis
- Weight Gain
- Fewer Extrapyramidal Side Effects
- Fewer Anticholinergic Side Effects
Risperidone (Risperdal)
- Atypical Antipsychotic
- Schizophrenia
- Bipolar Mania
- Autism-Associated Irritability
- Extrapyramidal Symptoms
- Hyperprolactinemia
- Gynecomastia
- Galactorrhea
- Amenorrhea
- Prolonged QT
- Intramuscular Long Acting (Depot) Form
Clozapine (Clozaril)
- Atypical Antipsychotic
- Schizophrenia
- Levodopa-Induced Psychosis
- Weight Gain
- Hypersalivation (Sialorrhea)
- Myocarditis
- Agranulocytosis
- Sedation
- Orthostatic Hypotension
- Constipation (Risk of Bowel Ileus)
- Weekly Lab Tests
Aripiprazole (Abilify)
- 2nd Generation Atypical Antipsychotic
- Schizophrenia
- Bipolar Disorder
- Depression
- Headache
- Dizziness
- Nausea and Vomiting
- Insomnia
- Anxiety
- Low Risk of Extrapyramidal Symptoms
- Lowest Risk of Weight Gain
Lithium
- Bipolar Disorder
- Mood Stabilizer
- Unknown Mechanism
- Nephrogenic Diabetes Insipidus
- Hypothyroidism
- Movement (Tremor)
- Heart Block
- Pregnancy (Ebstein's Anomaly)
Valproic Acid
- First Line Tonic-Clonic Seizure Treatment
- Bipolar Disorder
- Migraine Prophylaxis
- Increases GABA Concentration
- Blocks Voltage-Gated Na+ Channels
- GI Distress
- Contraindicated in Pregnancy
Valproic Acid (Valproate) Side Effects
- Vomiting
- Alopecia
- Liver Toxicity
- Pancreatitis/Pancytopenia
- Retain Fat (Weight Gain)
- Oedema (Edema)
- Appetite Increase
- Tremor
- Enzyme Inhibitor (P450)