Protein Synthesis Inhibitors
- 30S inhibitors
- Aminoglycosides
- Tetracyclines
- 50S inhibitors
- Chloramphenicol
- Clindamycin
- Erythromycin
- Lincomycin
- Linezolid
Chloramphenicol
- Bacteriostatic
- Inhibits 50S Peptidyltransferase Activity
- Meningitis
- Rocky Mountain Spotted Fever in Pregnant Women
- Anemia
- Aplastic Anemia
- Gray Baby Syndrome due to Decreased UDP-Glucuronyl Transferase
- Resistance Caused by Plasmid Encoded Acetyltransferase
Fluoroquinolones Toxicities
- Diarrhea
- Skin Rash
- Headache
- Tendon Rupture in Adults
- Myalgias in Kids
- Damage to Cartilage
- Teratogen
- QT Prolongation
Fluoroquinolones Antibiotics
- -floxacin
- Inhibits Topoisomerase II & IV
- Bactericidal
- Gram-negative Rods
- Pneumonia
- Gastrointestinal Infections
- Urinary Tract Infection
- Genital Infections
- Levofloxacin
- Ciprofloxacin
- Has Pseudomonas Coverage
- Avoid Polyvalent Cations
Metronidazole
- Bactericidal
- Forms Free Radical Toxic Metabolites
- Damages DNA
- Giardia lamblia
- Entamoeba Histolytica
- Trichomonas
- Gardnerella
- Anaerobes
- Metallic taste
- Disulfiram like Reaction with Alcohol
Trimethoprim
- Bacteriostatic
- Inhibits Bacterial Dihydrofolate Reductase
- Causes Sequential Block of Folate Synthesis
- Used in Combination with Sulfamethoxazole
- Combination Used For Recurrent Urinary Tract Infections
- Shigella
- Salmonella
- Pneumocystis Jiroveci Pneumonia
- Decrease in Red and White Blood Cells
- Alleviated with Leucovorin Rescue