11 Beta-Hydroxylase Deficiency
- Decreased Cortisol
- Decreased Aldosterone
- Increased Sex Hormones
- Increased 11 Deoxycorticosterone (11 DOC)
- Hypertension
- Masculinization
17 Alpha Hydroxylase Deficiency
- Decreased Cortisol
- Decreased Sex Hormones
- Increased Mineralocorticoids (DOC)
- Hypertension
- Hypokalemia
- XY Externally Phenotypic Female
- No Internal Reproductive Structures Due to Mullerian Inhibitory Factor
- XX Externally Phenotypic Female
- Sexual Infantilism
21 Hydroxylase Deficiency
- Decreased Cortisol
- Increased 17 Hydroxyprogesterone
- Decreased Aldosterone
- Hypotension
- Increased Renin
- Hyperkalemia
- Female Pseudohermaphroditism
Pheochromocytoma
- Adrenal Medulla Tumor
- Increased Catecholamines
- Episodic Hypertension
- Diaphoresis
- Abdominal or Chest Pain
- Surgery
- Antihypertensives
- Phenoxybenzamine
- Metyrosine (Demser)
- Do Not Palpate Abdomen
Waterhouse-Friderichsen Syndrome
- Acute 1° Adrenal Insufficiency
- Adrenal Hemorrhage
- Hypotension
- Neisseria meningitidis
- DIC
Addison's Disease
- Chronic 1° Adrenal Insufficiency
- Atrophy
- Destruction
- Deficiency In Cortisol And Aldosterone
- Skin Hyperpigmentation
- Increased POMC
- Hypotension
- Hyperkalemia
- Acidosis
- Addisonian Crisis
- ACTH (Cosyntropin) Stimulation Test
- Exogenous Cortisol
Addisonian Crisis
- Severe Symptoms
- Shock
- High-Dose Hydrocortisone
- Large Volumes of IV Fluid
- Insulin with Dextrose
- Kayexalate
- Loop or Thiazide Diuretics
Cushing's Syndrome Characteristics
- More Common in Women
- Glucocorticoids
- Decreased ACTH
- Primary Adrenal Disease
- Increased ACTH
- Pituitary Adenoma (Cushing's Disease)
- Paraneoplastic: Small Cell Carcinoma
- CRF-releasing Tumors
Cushing's Syndrome Symptoms And Diagnosis
- Osteoporosis
- Amenorrhea
- Truncal Obesity
- Skin Changes
- Buffalo Hump
- Immune Suppression
- Moon Facies
- Hypertension
- Decreased Insulin Sensitivity
- 24-hour urine free Cortisol
- Dexamethasone Suppression Test
Syndrome Of Apparent Mineralocorticoid Excess (SAME)
- 11 Beta-Hydroxysteroid Dehydrogenase Deficiency
- Elevated Cortisol
- Low Renin
- Low Aldosterone
- Autosomal-Recessive
- Licorice (glycyrrhetinic acid) Ingestion
- Hypertension
- Hypokalemia
- Metabolic Alkalosis
- Potassium-Sparing Diuretics
Neuroblastoma Characteristics and Presentation
- Malignant Neuroendocrine Tumor
- Neural Crest Cells Origin
- Sympathetic Ganglia
- Adrenal Glands
- Amplification of N-myc Oncogene
- Most Common Cancer In Infancy
- Abdominal Mass That Can Cross Midline
- Gastrointestinal Distress
- Metastasis
- Raccoon Eyes
- Opsoclonus-Myoclonus Syndrome
Neuroblastoma Diagnosis and Management
- 24-hour Urine Test
- Increased Catecholamines
- Increased Homovanillic and Vanillylmandelic Acid
- Ultrasound
- Magnetic Resonance Imaging (MRI)
- Biopsy
- Small Round Blue Cells
- Homer-Wright Rosettes
- Bombesin Positive
- Neuron Specific Enolase Positive
- Local Excision
- Chemotherapy
- Radiation
Adrenoleukodystrophy
- X-linked Recessive
- Peroxisome Dysfunction
- ABCD1 Mutation
- Adrenal Insufficiency
- Leukoencephalopathy
- Testicular Insufficiency
- Increased Very Long-chain Fatty Acids (VLCFA)
- Demyelination
- Genetic Testing
- Lorenzo's Oil
- Hematopoietic Stem Cell Transplantation
Primary Hyperaldosteronism
- Increased Aldosterone Secretion
- Adrenal Adenoma
- Bilateral Adrenal Hyperplasia
- Hypertension
- Hypokalemic Metabolic Alkalosis
- No Significant Edema
- Increased Aldosterone
- Decreased Renin
- Abdominal CT Scan
- Aldosterone Antagonists
- Surgery
Peripheral Precocious Puberty
- Secondary Sex Characteristics before 8 Years (Girls) or 9 Years (Boys)
- Breast Development (Girls) or Testicular Enlargement (Boys)
- GnRH Independent
- Congenital Adrenal Hyperplasia
- Exogenous Sex Steroids
- Granulosa Cell Tumor
- Non-Germ Cell Tumor
- GnRH Stimulation Test
- No Increase in LH
- Bone Age
- Hormone Levels
- Treating Underlying Disorders