Normal Gap Metabolic Acidosis (+HARD-ASS)

Hyperalimentation in the form of overeating and Total Parenteral Nutrition (TPN) are causes for normal gap metabolic acidosis.

Addison's disease, where there is a loss of aldosterone, leads to metabolic acidosis because of decreased activity of the the H+/ATPase pump in the intercalated cells of the collecting duct. As hydrogen is not secreted, due to a lack of aldosterone, H+ is retained inside the cells and consequently causes blood acidemia.

Renal tubular acidosis is another cause of normal gap metabolic acidosis. There is an accumulation of acid in the body due to the inability of the kidneys to appropriately acidify the urine.

Diarrhea is a common cause of normal gap metabolic acidosis due to excessive loss of bicarbonate through the GI tract.

Carbonic anhydrase inhibitors, such as acetazolamide, cause loss of bicarbonate in the urine, which can lead to a normal gap metabolic acidosis.

Spironolactone, which blocks aldosterone's effects on the distal tubule, can cause a normal gap metabolic acidosis. This is because a lack of aldosterone causes the sodium-hydrogen exchanger to waste sodium in the urine, leaving H+ in the serum.

Normal gap metabolic acidosis can sometimes be caused by rapid infusion or sufficiently large volumes of plasma expanders, such as normal saline.