Master Alpha 1 Receptor with Picmonic for Physician Assistant

The alpha 1 adrenergic receptor is a G protein coupled-receptor (GPCR) that is associated with the Gq subunit. The Gq subunit activates phospholipase C, which hydrolyzes PIP2 to DAG and IP3 in signal transduction pathways. DAG then acts as a second messenger that activates protein kinase C, and IP3 plays a role in phosphorylation of certain proteins.

Activation of this receptor in the smooth muscle of blood vessels leads to vasoconstriction of both arteries and veins, leading to increased blood pressure seen in the sympathetic response.

Alpha 1 receptors are present in the pupillary dilator muscles. Activation leads to an increase in pupillary dilator muscle contraction, also known as mydriasis. This is responsible for pupil dilation seen in the sympathetic response.

Activation of alpha 1 receptors leads to increase contraction of intestinal and bladder sphincter muscles. This leads to decreased micturition and defecation during times of stress.