Fentanyl, Methadone, and Oxycodone
- Mu-opioid receptor agonist (C)
- Fentanyl
- Highly lipid-soluble (C)
- Strong agonist (C)
- Severe analgesia after identification of dose level via other opioid (e.g., morphine) (C)
- Intraspinal administration possible (C)
- Do not change dose more than 1/week (long half-life) (C)
- IV, transdermal (C)
- Methadone (C)
- Chronic, severe pain (C)
- Treatment of heroin and opioid addicts (C)
- 90% bound to plasma protein (C)
- Accumulates in tissues (thus, extended duration of action) (C)
- Do not change dose more than 1/week (long half-life) (C)
- Oxycodone
- Moderate to severe analgesia (C)
- Extended Release (C)