Andrew Shared "HSF Week 09" - 15 Picmonics
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HSF Week 09
Systemic Lupus Erythematosus (SLE) Mechanism, Treatment and Complications
- Mechanism and Characteristics
- Systemic Autoimmune Disease
- 9:1 female to male ratio
- Treatment
- Glucocorticoids
- NSAIDS
- Hydroxychloroquine
- Cyclophosphamide
- Complications
- Lupus nephritis
- Libman-Sacks Endocarditis
- Secondary Antiphospholipid Antibody Syndrome
- Other
- Drug-induced lupus
2 mins
Sulfonamides Side Effects
- Side Effects
- Hypersensitivity
- Nephrotoxicity
- Photosensitivity
- Kernicterus in Infants
- Displaces Warfarin from Albumin
- Considerations
- Hemolysis with G6PD Deficiency
3 mins
Anti-glomerular Basement Membrane Antibodies
- Glomerulonephritis
- Goodpasture's Disease
- Linear immunofluorescence
- Hemoptysis
- Hematuria
1 min
Alport Syndrome
- Pathophysiology
- Nephritic
- X-linked
- Mutation in Type IV Collagen
- Diagnosis
- Split Basement Membrane
- Basket Weave Appearance
- Signs and Symptoms
- Ocular Disorders
- Deafness
2 mins
Minimal Change Disease
- Pathophysiology
- Nephrotic
- Most Common in Children
- May be Triggered by Recent Infection or Immune Stimulus
- Diagnosis
- On Electron Microscopy (EM) See Foot Process (Podocyte) Effacement
- On Light Microscopy (LM) See Normal Glomeruli
- Loss of Negative Charge
- Selective Loss of Albumin
- Treatment
- Responds to Corticosteroids
2 mins
Nephrotic Syndrome
- Signs and Symptoms
- Massive Proteinuria > 3.5g per Day
- Edema
- Increased risk of infection
- Thromboembolism
- Hyperlipidemia
- Fatty casts
1 min
Nephritic Syndrome
- Inflammatory
- Hematuria
- RBC casts
- Increased Nitrogen in blood
- Oliguria
- Hypertension
- Proteinuria < 3.5 grams per day
2 mins
Post Streptococcal Glomerulonephritis
- Pathophysiology
- Nephritic
- Children
- Signs and Symptoms
- Edema
- Cola Colored Urine
- Follows Group A Streptococcal pharyngitis or Skin Infection
- Diagnosis
- Neutrophils
- Immunofluorescence (IF) Granular
- Lumpy Bumpy Appearance on Immunofluorescence (IF)
- Subepithelial Immune Complex Humps
2 mins
Diabetic Glomerulonephropathy
- Pathophysiology
- Nonenzymatic Glycosylation of Glomerular Basement Membrane
- Nonenzymatic Glycosylation of Arterioles
- Hyperfiltration
- Increased GFR
- Histological Findings
- Hyaline Arteriolosclerosis
- Mesangial Expansion
- Type IV Collagen Deposition
- Kimmelstiel Wilson Lesions
- Presentation
- Nephrotic
2 mins
E. coli Overview
- Characteristics
- Gram-Negative
- Bacillus
- Purple Colony with Metallic Green Sheen
- Lactose-Fermenting
- Pink on MacConkey Agar
- Disease
- Diarrhea
- Lipid A Septic Shock
- P Pili Pyelonephritis and Cystitis
- K Capsule Neonatal Meningitis
- K Capsule Pneumonia
- H Antigen Flagella
2 mins
Pelvic Bones
- Ilium
- Iliac Crest
- ASIS (Anterior Superior Iliac Spine)
- AIIS (Anterior Inferior Iliac Spine)
- Acetabulum
- Pubis
- Pubic Symphysis
- Obturator Foramen
- Ischium
- Sacrum
- Coccyx
1 min
Pelvic Inflammatory Disease (PID)
- Mechanism
- Neisseria gonorrhoeae
- Chlamydia Trachomatis
- Symptoms
- Cervical Motion Tenderness
- Chandelier Sign
- Salpingitis
- Tubo-ovarian abscess
- Hydrosalpinx
- Complications
- Ectopic Pregnancy
- Infertility
- Adhesions
- Fitz-Hugh-Curtis Syndrome
2 mins
Endometriosis Characteristics
- Endometrial Tissue Outside of Uterus
- Glands and Stroma
- Most Common in Ovary, Pelvis, Peritoneum and Bowels
- "Chocolate Cyst" in Ovary
- Adenomyosis
- Theories
- Retrograde Flow
- Metaplastic Transformation
- Mullerianosis
2 mins
Endometriosis Symptoms and Treatment
- Symptoms
- Dysmenorrhea
- Cyclic Pelvic Pain
- Dyschezia
- Dysuria
- Dyspareunia
- 30-40% are Infertile
- Treatment
- Surgery
- NSAIDs
- OCPs
- Progesterone (Progestins)
- GnRH Agonists
1 min
Polycystic Ovarian Syndrome (PCOS) Symptoms and Diagnosis
- Symptoms
- Most Common Cause of Infertility in Women
- Amenorrhea
- Acne
- Hirsutism
- Obesity
- Diagnosis
- Enlarged, Cystic Ovaries
- LH:FSH Ratio of 3:1
- "String of Pearls" on Ultrasound
1 min
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