Petter Shared "Boards Review" - 60 Picmonics
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Boards Review
Papillary Thyroid Carcinoma
- Characteristics
- Most Common Thyroid Cancer
- Excellent Prognosis
- Lymphatic Spread
- Diagnosis
- Orphan Annie Nuclei
- Empty Nuclei with Central Clearing
- Psammoma Bodies
- Risk Factors
- Head and Neck Radiation
- RET and BRAF Mutations
- Gardner Syndrome
- Cowden Syndrome
2 mins
Medullary Thyroid Carcinoma
- Sporadic and Familial Types
- Arises from Parafollicular C cells
- Produces Calcitonin
- Hypocalcemia
- May Produce ACTH
- Diagnosis
- Sheets of Cells With Amyloid Deposition
- Increased Calcitonin with Pentagastrin Infusion
- Risk Factors
- MEN 2A and 2B
2 mins
Follicular Thyroid Carcinoma
- Characteristics
- Most Common to Present as Solitary Cold Nodule
- Hematogenous Spread
- Good Prognosis
- Histological findings
- Uniform Follicles
- May Invade Capsule
- Risk factors
- Head and Neck Radiation
1 min
Anaplastic Thyroid Cancer
- Pathophysiology
- Rapidly Progressive
- Poor Prognosis
- Hoarseness
- Diagnosis
- Invades Local Structures
- Mixed Morphology
- Risk Factors
- Multinodular Goiter
- Older Age
- History of Thyroid Disease
2 mins
MEN 1 (Multiple Endocrine Neoplasia)
- Pathophysiology
- Autosomal Dominant
- Menin Mutation (Tumor Suppression Gene)
- Chromosome 11
- Signs and Symptoms
- Pancreatic Endocrine Tumors
- Pituitary Tumors
- Parathyroid Adenomas
2 mins
MEN 2A (Multiple Endocrine Neoplasia)
- Pathophysiology
- Autosomal Dominant
- RET Gene
- Signs and Symptoms
- Medullary Thyroid carcinoma
- Calcitonin
- Parathyroid
- Pheochromocytoma
45 secs
MEN 2B (Multiple Endocrine Neoplasia)
- Pathophysiology
- RET Gene
- Autosomal Dominant
- Signs and Symptoms
- Medullary Thyroid Carcinoma
- Pheochromocytoma
- Mucosal Neuromas
- Marfanoid Body Habitus
2 mins
11 Beta-Hydroxylase Deficiency
- Pathophysiology
- Decreased Cortisol
- Decreased Aldosterone
- Increased Sex Hormones
- Increased 11 Deoxycorticosterone (11 DOC)
- Signs and Symptoms
- Hypertension
- Masculinization
1 min
21 Hydroxylase Deficiency
- Pathophysiology
- Decreased Cortisol
- Increased 17 Hydroxyprogesterone
- Decreased Aldosterone
- Signs and Symptoms
- Hypotension
- Increased Renin
- Hyperkalemia
- Female Pseudohermaphroditism
2 mins
17 Alpha Hydroxylase Deficiency
- Decreased Cortisol
- Decreased Sex Hormones
- Increased Mineralocorticoids (DOC)
- Hypertension
- Hypokalemia
- XY Externally Phenotypic Female
- No Internal Reproductive Structures Due to Mullerian Inhibitory Factor
- XX Externally Phenotypic Female
- Sexual Infantilism
2 mins
Pheochromocytoma
- Cause/Mechanism
- Adrenal Medulla Tumor
- Increased Catecholamines
- Assessment
- Episodic Hypertension
- Diaphoresis
- Abdominal or Chest Pain
- Interventions
- Surgery
- Antihypertensives
- Phenoxybenzamine
- Metyrosine (Demser)
- Considerations
- Do Not Palpate Abdomen
3 mins
Acute Myelogenous Leukemia (AML)
- Myeloblasts Increase on Peripheral Smear
- Median Onset 60 Years
- T 15;17 M3 Subtype
- Auer Rods
- Disseminated Intravascular Coagulation (DIC) is a Common Presentation
- M5 Gum Infiltration
- Responds to Vitamin A
3 mins
Chronic Myelogenous Leukemia (CML)
- Pathophysiology
- BCR-ABL
- 9;22 Translocation
- Philadelphia Chromosome
- Signs & Symptoms
- Tyrosine Kinase
- Low Alkaline Phosphatase
- Splenomegaly
- Considerations
- Blast Crisis
- Age 30 to 90 Years
- Responds to Imatinib
3 mins
Acute Lymphoblastic Leukemia (ALL)
- Ages < 15
- May Present with Bone Marrow Involvement in Children
- Mediastinal Mass in Adolescents
- TdT Positive
- CALLA Positive
- t(12;21) Better Prognosis
- Spread to CNS and Testes
- Most Responsive to Chemotherapy
2 mins
Chronic Lymphocytic Leukemia (CLL)
- Signs and Symptoms
- Age > 60 Years
- B Cell Neoplasm
- Smudge Cells
- Often Asymptomatic
- Cold IgM Autoimmune Hemolytic Anemia
- Warm IgG Autoimmune Hemolytic Anemia
- Richter's Transformation
3 mins
Hairy Cell Leukemia
- Pathophysiology
- Mature B Cell Tumor
- Signs and Symptoms
- Splenomegaly
- Diagnosis
- Flow Cytometry
- Cells Have Filamentous Hair-Like Projections
- Stains TRAP Positive
- Dry Tap on Bone Marrow Aspiration
- Treatment
- Cladribine
- Pentostatin
2 mins
Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
2 mins
Follicular Lymphoma
- Derives from Germinal Center
- Occurs in adults
- T14;18
- BCL 2 overexpression
- BCL 2 inhibits apoptosis
- Indolent
- Generalized lymphadenopathy
- Bone marrow involvement
2 mins
Mantle Cell Lymphoma
- Older Males
- Activation of Cyclin D Gene
- T 11;14
- CD5
- Poor Prognosis
55 secs
Adult T Cell Lymphoma
- Caused by HTLV 1
- Japan, West Africa, Caribbean
- Present with cutaneous lesions
- Aggressive
1 min
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