Vasoactive intestinal polypeptide (VIP) and VIPoma
- SOURCE: Parasympathetic ganglia in sphincters, gallbladder, small intestine
- ACTION: Increases intestinal water and electrolyte secretion
- Increases relaxation of intestinal smooth muscle and sphincters
- REGULATION: Increased by distention and vagal stimulation
- Decreased by adrenergic input
- non-α, non-β islet cell pancreatic tumor that secretes VIP.
- Men 1 Association
- Watery Diarrhea that persists with fasting: often greater than 3 L/day (pancreatic cholera)
- Hypokalemia
- Achlorhydria
- Treatment: Octreotide