Ken Shared "UGC Picmaster Challenge" - 8 Picmonics
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UGC Picmaster Challenge
Li-Fraumeni's
- Pathophysiology
- Li-Fraumeni
- autosomal dominant
- TP53
- Clinical
- SBLA cancer syndrome
- Sarcoma
- Breast cancer
- Leukemia
- Adrenal tumors
46 secs
Familial Hyperchylomicronemia (Type I)
- Autosomal-Recessive
- Lipoprotein Lipase Deficiency
- ApoCII Deficiency
- Elevated Chylomicrons
- Complications
- Acute Pancreatitis
- Pruritic Xanthomas
- Hepatosplenomegaly
- Diagnosis
- Creamy Supernatant
Waldenstrom Macroglobulinemia
- B-cell lymphoma with monoclonal IgM production
- Generalized lymphadenopathy
- Increased serum proteins with M spike (comprised of IgM)
- Bleeding - viscous serum results in defective platelet aggregation
- Cold Agglutinin Autoimmune Hemolytic Anemia (C-AIHA)
- Raynaud phenomenon
- Visual and neurologic deficits (e.g. retinal hemorrhage or stroke) - IgM (large pentamer) causes serum hyperciscosity
- Treatment
- Acute complications: plasmapheresis (removes IgM from the serum)
1 min
Potter Sequence (Syndrome)
- PATHOGENESIS
- Oligohydramnios
- clinical findings
- Limb Deformities
- Facial Anomalies
- Pulmonary Hypoplasia Most Common Cause of Death
- CAUSES
- Autosomal Recessive Polycystic Kidney Disease (ARPKD)
- Posterior Urethral Valves
- Chronic Placental Insufficiency
- Bilateral Renal Agenesis
3 mins
Class II Anti-arrhythmic (Beta-blockers)
- Indication
- Supraventricular tachycardia
- Ventricular rate control for atrial fibrillation and atrial flutter
- Side Effects
- COPD and Asthma Exacerbation
- Impotence
- Adverse CNS effects
- Cardiovascular Effects of Beta-Blockers
- Mask Hypoglycemia
- Drug specific side effects
- Propranolol
- Vasospasm in Prinzmetal's Angina
- Alpha-1-agonism if given alone for Pheochromocytoma and Cocaine
- Metoprolol
- Dyslipidemia
- Overdose
- Saline Infusion
- Atropine
- Glucagon
- Mechanism of Action
- Decreases SA and AV node activity (phase 4 depolarization)
- Contraindicated in Wolf-Parkinson-White
- Decreases mortality in CHF
- Hypotension, Bradycardia, Heart Block, Bronchospasm (SE)
Dubin Johnson Syndrome (with Audio)
- Pathophysiology
- defective hepatocyte secretion in to proper canal
- Autosomal recessive- "hereditary conjugated hyperbilirubinemia"
- Absent MRP2 (multidrug resistant protein)
- Error is inside the hepatocyte.... NOT due to a clogged bile duct
- Signs/symptoms
- Liver changes from Brown to Black
- Jaundiced (otherwise asymptomatic)
- labs
- Conjugated hyperbilirubinemia
- Treatment
- NO excess urinary coproporphyrins
- no treatment necessary (benign disease)
6 mins
Familial Adenomatous Polyposis
- Pathophysiology
- Autosomal Dominant
- APC
- Chromosome 5
- Management
- Begin screening at 10-12 years old
- Prophylactic removal of colon
- Gardner Syndrome
- Gardner syndrome
- Osteomas
- Dental Abnormalities
- Soft Tissue Tumors
- Congenital hypertrophy of retinal pigment epithelium
- Turcot Syndrome
- Turcot Syndrome
- Medulloblastoma
- CNS tumor
2 mins
Dantrolene
- Complications
- Hepatotoxicity
- Excessive Tears
- Tachycardia
- Uticaria
- Drowsy
- Vision Changes
- Muscle Weakness
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