MK Shared "1.2 FA Biochemistry" - 106 Picmonics
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1.2 FA Biochemistry
Nucleus
- Characteristics
- Transcription Factors
- Nucleolus Transcribes rRNA
- DNA
- RNA
- Nuclear Membrane is a Bilayer
- Membrane is Continuous with Endoplasmic Reticulum
- Nucleus Surrounded by Cytosol
- Nuclear Pores
2 mins
Chromosome Forms
- Characteristics
- Chromosome
- Sister Chromatids
- Homologous Recombination
- Tetrad
2 mins
Chromosome Components
- Characteristics
- DNA
- Histones
- Nucleosomes
- Chromatin
- Chromosome
- Telomere
1 min
DNA Base Pairing
- Characteristics
- 3' End
- 5' End
- Antiparallel Base Pairing
- Complementary Strands Pair
- Thymine And Adenine Pair
- 2 Hydrogen Bonds
- Adenine and Uracil Pair in RNA
- Guanine And Cytosine Pair
- 3 Hydrogen Bonds
3 mins
Orotic Aciduria
- Pathophysiology
- Autosomal Recessive
- Defect in UMP Synthase
- De Novo Pyrimidine Synthesis Pathway
- Symptoms
- Increased Orotic Acid in Urine
- Megaloblastic Anemia
- No Response to B12 or Folate
- Non-Hyperammonemic
- Failure to Thrive
- Treatment
- Oral Uridine Monophosphate
2 mins
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Trimethoprim
- Mechanism of Action
- Bacteriostatic
- Inhibits Bacterial Dihydrofolate Reductase
- Causes Sequential Block of Folate Synthesis
- Used in Combination with Sulfamethoxazole
- Combination Used For Recurrent Urinary Tract Infections
- Indications
- Shigella
- Salmonella
- Pneumocystis Jiroveci Pneumonia
- Side Effects
- Decrease in Red and White Blood Cells
- Alleviated with Leucovorin Rescue
2 mins
Ribavirin
- Mechanism
- Hypermutation in RNA Viruses
- Inhibits Inosine Monophosphate Dehydrogenase
- Indications
- Hepatitis C
- Viral Hemorrhagic Fevers
- Respiratory Syncytial Virus (RSV)
- Side Effects
- Hemolytic Anemia
- Teratogen
1 min
Gout Treatment
- Acute (Acute-angle)
- NSAIDs
- Glucocorticoids
- Colchicine
- Impairs Leukocyte Chemotaxis
- Chronic Gout (Crone Goat)
- Inhibit Xanthine Oxidase
- Allopurinol
- Febuxostat
- Inhibit Reabsorption of Uric Acid
- Probenecid
1 min
Adenosine Deaminase Deficiency
- Adenosine to Inosine
- Excess ATP
- Inhibition of Ribonucleotide Reductase
- Prevents DNA Synthesis
- Decreases B Cells and T Cells
- Major cause of SCID
1 min
Lesch-Nyhan Syndrome
- X-linked Recessive
- Absence of HGPRT
- Hypoxanthine to IMP
- Guanine to GMP
- Excess uric acid
- Gout
- Retardation
- Self-mutilation
- Choreoathetosis
- PRPP is increased
2 mins
DNA Replication
- Characteristics
- DNA Gyrase Uncoils Supercoil
- Helicase Separated DNA Strand
- Single-Strand Binding (SSB) Protein Keeps Strands Separated
- DNA Polymerase Synthesizes New Strand
- 3' To 5' Reading
- Primase Creates RNA Primer
- Telomerase Caps DNA Ends
- DNA Ligase Combines Okazaki Fragments
- Okazaki Fragments On Lagging Strand
4 mins
Transcription Overview
- Initiation
- RNA Polymerase Binds Promoter
- Elongation
- DNA Opens by Helicase
- RNA Polymerase Reads 3' to 5'
- Nucleotides Added to 3' End
- Termination
- Stem Loop Formation
- Rho Protein Factor
3 mins
RNA
- Characteristics
- mRNA
- 3' Poly A Tail
- 5' Cap
- Template For Translation
- rRNA
- Catalyzes Amino Acid Bonds
- Component of Ribosome Enzyme
- tRNA
- Anticodon Region
- 3' Tail Bind To Amino Acid
2 mins
Eukaryotic Post Transcriptional Modification
- Modifications in Nucleus
- mRNA Splicing
- Introns Cut Out
- Exons spliced together
- Alternate Splicing
- 5' Cap added
- 3' Poly A tail added
- Transported to Cytosol
2 mins
Translation: Initiation
- Translation: Initiation
- Ribosome Binds mRNA
- Complex Reads 5' to 3'
- AUG Start Codon
- Initiation Complex Forms
- GTP and Initiation Factor Bring Complex Together
- Met-tRNA Binds P Site
- tRNA With Bound Amino Acids Binds A Site
- Amino Acid Chain Created in Elongation
3 mins
Translation: Elongation & Termination
- Translation: Elongation
- Amino Acid Chain Is Created
- New Amino Acid-tRNA Enters A Site
- GTP and Elongation Factors Help tRNA Enter A Site
- Peptide Chain Binds to New Amino Acid
- Peptide Chain-tRNA Moves to P Site
- Free tRNA in P Site Moves to E Site
- Translation: Termination
- Stop Codon at A Site Causes Termination
- Release Factors Help Complex Disassociate
- Complex Falls Apart
3 mins
Prophase
- Nuclear Membrane Disintegrates
- Centrioles Migrate
- Spindle Apparatus Forms
- Meiosis I starts Diploid
- Homologous Chromosomes form Tetrads
- Tetrads Cross Over
- Meiosis II starts Haploid
- Mitosis starts Diploid
- Sister Chromatid Pairs Stay Separated
2 mins
Metaphase
- Characteristics
- Microtubules Extend from Centrioles' Spindles
- Centromere
- Kinetochore
- Meiosis I Tetrads Aligned at Metaphase Plate
- Meiosis II Sister Chromatids Aligned at Metaphase Plate
- Mitosis Sister Chromatids Aligned at Metaphase Plate
57 secs
Anaphase
- Spindle Microtubules from Centrioles Split Pairs
- Meiosis I Tetrad Splits into Two Sister Chromatid Pairs
- Meiosis II Sister Chromatid Pair Splits into Two Chromatids
- Mitosis Sister Chromatid Pair Splits into Two Chromatids
1 min
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