Daulat Shared "Anemia" - 21 Picmonics
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Anemia
Microcytic Anemia Causes
- MCV < 80
- Causes
- Thalassemias
- Chronic Disease or Illness
- Lead Toxicity
- Late Iron Deficiency
- Sideroblastic Anemia
1 min
Normocytic Nonhemolytic Anemia Causes
- MCV 80-100
- Nonhemolytic
- Anemia of Chronic Disease/Inflammation
- Aplastic Anemia
- Chronic Kidney Disease
- Early Iron Deficiency
1 min
Normocytic Hemolytic Anemia Causes
- Intrinsic Hemolytic
- Hereditary Spherocytosis
- RBC Enzyme Deficiency
- Hemoglobin C Defect
- Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Sickle Cell Anemia
- Extrinsic Hemolytic
- Autoimmune
- Microangiopathic
- Mechanical Destruction
- Prosthetic Cardiac Valves
- Infection
- Snake Venom
2 mins
Macrocytic Anemia Causes
- MCV > 100
- Megaloblastic
- B12 Deficiency
- Folate Deficiency
- Orotic Aciduria
- Non Megaloblastic
- Alcoholism
- Liver Disease
- Reticulocytosis
2 mins
Anemia Lab Values
- Iron Deficiency Anemia
- Serum Iron Decreased
- Transferrin Increased
- Ferritin Decreased
- % Transferrin Saturation Decreased
- Pregnancy and OCP Use
- Serum Iron Normal
- Transferrin Increased
- Ferritin Normal
- % Transferrin Saturation Decreased
- Anemia of Chronic Disease
- Serum Iron Decreased
- Transferrin Decreased
- Ferritin Increased
- % Transferrin Saturation Decreased or Normal
- Hemochromatosis
- Serum Iron Increased
- Transferrin Decreased
- Ferritin Increased
- % Transferrin Saturation Increased
3 mins
Iron Deficiency Anemia
- Causes
- Malnutrition/Malabsorption
- Hemorrhage
- Signs
- Microcytic, Hypochromic Anemia
- Decreased Heme Synthesis
- Labs
- Decreased Reticulocytes
- Decreased Ferritin
- Increased Red Cell Distribution Width (RDW)
- Poikilocytosis
- Anisocytosis
- Increased Central Pallor
2 mins
Cold Agglutinin Autoimmune Hemolytic Anemia (C-AIHA)
- Pathophysiology
- IgM Binds to RBCs at Cold Temperatures (28-31C)
- Extravascular Hemolysis
- Waldenstrom's Macroglobulinemia
- Mycoplasma Pneumoniae
- Infectious Mononucleosis
- Lymphomas and CLL
- Symptoms
- Acrocyanosis with Cold Exposure
- Blue Fingers and Toes
- Diagnosis
- Positive Coombs Test
- Treatment
- Avoid Cold
- Rituximab
- +/- Fludarabine
4 mins
Warm Agglutinin Autoimmune Hemolytic Anemia (W-AIHA)
- Pathophysiology
- Most Common Autoimmune Hemolytic Anemia
- IgG Coats RBCs at Warm Temperatures
- Fc Portion of IgG Recognized By Macrophages
- Extravascular Hemolysis
- Medications
- Alpha Methyldopa
- Chronic Lymphocytic Leukemia (CLL)
- Systemic Lupus Erythematosus (SLE)
- Diagnosis
- Positive Coombs Test
- Treatment
- Corticosteroids
- Splenectomy
- Intravenous Immunoglobulin (IVIG)
- Rituximab
3 mins
Selective IgA Deficiency
- Pathophysiology
- Defect in Class Switching
- Decreased IgA
- Signs and Symptoms
- Often Asymptomatic
- Increase in Atopic & Autoimmune Diseases
- Sinopulmonary Infections
- Increased Risk Giardia Lamblia Infections
- Inflammatory Bowel Disease
- Celiac Disease
- Considerations
- Anaphylaxis From IgA Containing Blood Products
2 mins
Common Variable Immunodeficiency
- Pathophysiology
- Defect in B Cell Maturation
- Decreased Plasma Cells
- Decreased Immunoglobulins
- Signs & Symptoms
- Sinopulmonary Infections
- Increased Risk of Autoimmune Disease
- Lymphoma
1 min
Polycythemia Vera Disease
- Pathophysiology
- JAK2 Mutation leading to increased red blood cells
- Tyrosine Kinase
- Symptoms
- Erythromelalgia
- Pruritus
- Often After Hot Shower
- Headache
- Treatment
- Phlebotomy
- Aspirin
1 min
Acute Myelogenous Leukemia (AML)
- Myeloblasts Increase on Peripheral Smear
- Median Onset 60 Years
- T 15;17 M3 Subtype
- Auer Rods
- Disseminated Intravascular Coagulation (DIC) is a Common Presentation
- M5 Gum Infiltration
- Responds to Vitamin A
3 mins
Chronic Myelogenous Leukemia (CML)
- Pathophysiology
- BCR-ABL
- 9;22 Translocation
- Philadelphia Chromosome
- Signs & Symptoms
- Tyrosine Kinase
- Low Alkaline Phosphatase
- Splenomegaly
- Considerations
- Blast Crisis
- Age 30 to 90 Years
- Responds to Imatinib
3 mins
Leukemia Assessment
- Cause
- Immature WBCs
- Assessment
- Recurrent Infections
- Easy Bruising
- Bleeding
- Anemia
- Fatigue
- Weight Loss
- Bone Pain
- Considerations
- May Have Normal or High WBC Count
2 mins
Multiple Myeloma Pathophysiology
- Pathophysiology
- Monoclonal Plasma Cell Cancer
- Clock Face Chromatin
- Diagnosis
- M Spike on Protein Electrophoresis
- Increased IgG and IgA
- Fried Egg Appearance (BM Biopsy)
- Rouleaux Formation
- Stacked RBC's
- Bence Jones Protein
2 mins
Multiple Myeloma Signs and Symptoms
- Signs and Symptoms
- Increased Susceptibility to Infection
- Back/Bone Pain
- Punched Out Lytic Bone Lesions
- Hypercalcemia
- Primary Amyloidosis
- Renal Insufficiency
- Anemia
2 mins
Polymyositis / Dermatomyositis Disease
- Pathophysiology
- Idiopathic Inflammatory Myopathy
- More Common in Women
- Endomysial Inflammation with CD8+ Cells (Polymyositis)
- Perimysial Inflammation with CD4+ Cells (Dermatomyositis)
- Signs and Symptoms (Both)
- Symmetric Proximal Muscle Weakness
- Dysphagia
- Lung and Cardiac Involvement
- Signs and Symptoms (Dermatomyositis)
- Malar Rash
- Shawl-like Shoulder Rash
- Gottron Papules on Knuckles
- Heliotrope Rash
3 mins
Polymyositis / Dermatomyositis Diagnosis and Treatment
- Diagnosis
- Increased CK (CPK)
- Increased Aldolase
- Anti-JO-1 Antibody
- Anti-SRP Antibody
- Antinuclear Antibody
- Abnormal EMG
- Biopsy
- Treatment
- Corticosteroids
- Methotrexate
- Azathioprine
- Treatment For Resistant Disease
- Intravenous Immunoglobulin (IVIG)
- Cyclophosphamide
- Rituximab
- Calcineurin Inhibitors
2 mins
Systemic Lupus Erythematosus (SLE) Diagnosis and Clinical Features
- IM DAMN SHARP acronym
- Immunoglobulins
- Malar rash
- Discoid rash
- Antinuclear antibody
- Mucositis
- Neurologic disorders
- Serositis
- Hematologic disorders
- Arthritis
- Renal disorders
- Photosensitivity
2 mins
Systemic Lupus Erythematosus (SLE) Mechanism, Treatment and Complications
- Mechanism and Characteristics
- Systemic Autoimmune Disease
- 9:1 female to male ratio
- Treatment
- Glucocorticoids
- NSAIDS
- Hydroxychloroquine
- Cyclophosphamide
- Complications
- Lupus nephritis
- Libman-Sacks Endocarditis
- Secondary Antiphospholipid Antibody Syndrome
- Other
- Drug-induced lupus
2 mins
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