Chris Shared "Pharmacology" - 300 Picmonics
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Pharmacology
Warfarin
- Mechanism of Action
- Interferes with Vitamin K-dependent Clotting Factors
- Extrinsic Pathway
- Bridge with Heparin
- Indications
- Chronic Anticoagulation
- Side Effects
- Bleeding
- Necrosis
- Cytochrome P450
- Contraindications
- Pregnancy
- Antidote
- FFP + Vitamin K
2 mins
Heparin Mechanisms
- Mechanism of Action
- Short Half-life
- Antithrombin Activation Cofactor
- Decrease Thrombin, Factor Xa
- Side Effects
- Bleeding
- Heparin Induced Thrombocytopenia (HIT)
- Antidote
- Protamine Sulfate
2 mins
Aminoglycosides
- Drug Names
- Gentamicin
- Neomycin for Bowel Surgery Prep
- Amikacin
- Tobramycin
- Streptomycin
- Mechanism of Action
- Bactericidal
- Inhibit Formation of Initiation Complex
- Cause Misreading of mRNA
- Require O2 for Uptake
- Resistance
- Resistance by Transferase Enzymes
- Acetylation
- Phosphorylation
- Adenylation
- Indications
- Gram-Negative Rod Infections
- Synergistic with B-Lactam Antibiotics
- Side Effects
- Nephrotoxicity Especially When Used with Cephalosporins
- Ototoxicity Especially When Used with Loop Diuretics
- Teratogen
5 mins
Vancomycin Mechanism
- Bacteriostatic and Bactericidal
- Gram-Positive
- Inhibits Cell Wall Mucopeptide
- Binds to D-ala D-ala
- Resistance with Change to D-ala D-lac
- Staphylococcus aureus
- Orally for Clostridium difficile
- Enterococci
2 mins
Fluoroquinolones Antibiotics
- -floxacin
- Mechanism of Action
- Inhibits Topoisomerase II & IV
- Bactericidal
- Indications
- Gram-negative Rods
- Pneumonia
- Gastrointestinal Infections
- Urinary Tract Infection
- Genital Infections
- Drugs
- Levofloxacin
- Ciprofloxacin
- Has Pseudomonas Coverage
- Considerations
- Avoid Polyvalent Cations
3 mins
Needle Sizes and Uses
- Adjust Size Based on Height/Weight
- Subcutaneous Injections
- 3/8 or 5/8 inch
- Intramuscular (IM)
- 1-1.5 inches
1 min
Peak and Trough
- Peak
- Highest Concentration
- Trough
- Lowest Level of Therapeutic Range
- Obtain Before Next Dose
- Half-Life
2 mins
Routes of Administration Part One
- Enteral Administration
- Oral
- Sublingual
- Buccal
- Rectal
- Tubes
- Topical or Mucous Membrane Administration
- Transdermal
- Drops/Spray
- Vaginal
- Inhalation Administration
- Inhalation
2 mins
Routes of Administration Part Two (Parenteral)
- Parenteral Administration
- Intradermal
- Subcutaneous
- Intramuscular (IM)
- Intravenous
- Epidural
- Intrathecal
- Intraosseous
- Intraperitoneal
2 mins
Intramuscular Medication (IM) Administration
- Risks
- Injury to Nerves, Bone, and Blood Vessels
- Sites
- Deltoid
- Vastus Lateralis
- Ventrogluteal
- Nursing Considerations
- Selection of Needle Length
- Aseptic Technique for Drawing Up
- Z-Track
- 90 Degree Angle
- Max Amount (2-5 mL Adult, 1 mL Child)
- Techniques to Reduce Pain
2 mins
Transdermal Medication Administration
- Application
- Patch or Disc
- Directly on Skin of Arms, Chest, Upper Back
- Benefits
- Avoids First Pass Metabolism
- Sustained Administration of Medication
- Nursing Considerations
- Clean Skin After Removal
- Rotate Sites of Patches
- Apply to Dry Skin
- Avoid Shaved Skin
- Avoid Heat
- Nitro Effects Lost After 24 Hours
2 mins
Ear Drops Medication Administration
- Indications
- Earwax Buildup
- Ear Infections
- Pulling The Pinna
- Child - Back and Downward
- Adult - Back and Upward
- Procedure
- Side-Lying with Ear Up
- Instill Medication
- Stay for 2-3 Minutes
- Nursing Considerations
- Room Temperature
- May Massage Tragus
- Perforated Eardrum
2 mins
Eye Medication Administration
- Procedure
- Supine with Neck Hyperextended
- Wash Away Crusts
- Cotton Ball on Cheekbone
- For Ophthalmic Drops
- Instill Drops into Conjunctival Sac
- Repeat if Missed or Patient Blinks
- 5 Minutes Before 2nd Medication
- For Ophthalmic Ointment
- Thin Stream Along Inner Edge
- Inner Canthus to Outer Canthus
2 mins
Alpha 1 Receptor
- Characteristics
- Gq Subunit
- Increase Vascular Smooth Muscle Contraction
- Increase Pupillary Dilator Muscle Contraction
- Increase Intestinal and Bladder Sphincter Muscle Contraction
1 min
Alpha 2 Receptor
- Characteristics
- Gi Subunit
- Decrease Sympathetic Outflow
- Decrease Insulin Release
- Decrease Lipolysis
- Increase Platelet Aggregation
- Decrease Aqueous Humor Production
2 mins
Beta-1 Receptor
- Characteristics
- Gs Protein Class
- Increased Heart Rate
- Increased Contractility
- Increase Renin Release
- Increased Lipolysis
44 secs
Beta-2 Receptor
- Characteristics
- Gs protein class
- Increased Heart Rate
- Increased Contractility
- Increased Lipolysis
- Increased Insulin
- Increased Aqueous Humor Production
- Ciliary Muscle Relaxation
- Vasodilation
- Bronchodilation
- Decrease Uterine Tone
2 mins
P450 Inhibitors
- Quinidine
- Ciprofloxacin
- Isoniazid
- Grapefruit Juice
- Acute Alcohol Use
- Erythromycin (Macrolide)
- Indinavir
- Cimetidine
- Sulfonamides
- Ketoconazole
- Amiodarone
2 mins
P450 Inducer
- Griseofulvin
- Phenytoin
- Carbamazepine
- Rifampin
- Barbiturates
- Chronic Alcohol Use
- St. John's Wort
51 secs
Benzodiazepine Antidote
- Antidote
- Flumazenil
40 secs
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