Michael Shared "Neuro" - 49 Picmonics
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Neuro
Lambert-Eaton Syndrome
- Mechanism
- Autoantibody to the Presynaptic Calcium Channel on Motor Neurons
- Inhibits Acetylcholine (ACh) Release at Neuromuscular Junction
- Paraneoplastic Syndrome
- Small Cell Lung Cancer
- Symptoms
- Proximal Muscle Weakness
- Improves with Muscle Use
- Autonomic Symptoms
- Extraocular Muscle Sparing
2 mins
Chemical Synapse
- Voltage-Gated Calcium Channels Open
- Ca2+ Influx
- Vesicle-Membrane Fusion
- Exocytosis of Neurotransmitter
- Neurotransmitter Binds Post-Synaptic Receptors
- Neurotransmitter Breakdown
- Neurotransmitter Reuptake
1 min
Skeletal Muscle Contraction Initiation
- Somatic Motor Neuron Releases Acetylcholine
- Acetylcholine Causes Sodium Influx
- Cell Reaches All-or-Nothing Threshold
- Voltage-Gated Calcium Channels Undergo Conformational Change
- Sarcoplasmic Reticulum Causes Calcium Flood
- Calcium Flood Enters Myofibrils
1 min
Electrical Synapse
- Characteristics
- Cardiac and Smooth Muscle Location
- Fast Transmission
- Bidirectional
- Presynaptic Na+ Floods Through Gap Junction
- Na+ Influx Initiates Postsynaptic Action Potential
2 mins
Clostridium tetani
- Characteristics
- Gram-Positive
- Bacilli
- Obligate Anaerobic
- Exotoxin
- Spore-Forming
- Renshaw Cells in the Spinal Cord
- Blocks Glycine and GABA Release
- Signs and Symptoms
- Spasms
- Risus Sardonicus
- Lockjaw
- Opisthotonus
3 mins
Clostridium botulinum
- Characteristics
- Bacillus
- Gram-positive
- Anaerobe
- Spore-forming
- Heat Labile Toxin
- Inhibits Acetylcholine (Ach) Release at Neuromuscular Junction (NMJ)
- Canned Food in Adults
- Spores in Honey
- Signs and Symptoms
- Descending Flaccid Paralysis
- Diplopia
- Ptosis
- Floppy Baby
- Constipation
2 mins
Posttraumatic Stress Disorder (PTSD)
- Assessment
- Re-experience Traumatic Event
- Flashbacks
- Nightmares
- Avoidance
- Self-destructive Behaviors
- Considerations
- Assess Suicide Risk
- Actively Listen to Stories
- Anxiety Medications
2 mins
Acetylcholinesterase Inhibitor Poisoning
- DUMBBELSS
- Diarrhea
- Urination
- Miosis
- Bronchospasm
- Bradycardia
- Emesis
- Lacrimation
- Salivation
- Sweating
2 mins
Acetylcholinesterase Inhibitor Antidote
- Antidote
- Atropine
- Pralidoxime
1 min
Myasthenia Gravis
- Mechanism
- Antibodies to Acetylcholine Receptor
- Symptoms
- Ptosis
- Diplopia
- Weakness with Muscle Use
- Respiratory Death
- Thymus Associated
- Treatment
- Acetylcholinesterase Inhibitors
- Plasmapheresis
- Thymectomy
1 min
Fluoxetine (Prozac)
- Mechanism of Action
- Inhibits Reuptake of Serotonin
- Indications
- Depression
- Side Effects
- Sexual Dysfunction
- CNS Stimulation
- Weight Changes
- Serotonin Syndrome
- Contraindications
- No MAO-Is
- No Anticoagulants / Antiplatelets
- Considerations
- Suicide Risk
- Delayed Onset of Action
2 mins
Succinylcholine
- Indications
- Inducing Paralysis
- Mechanism of Action
- Neuromuscular Blocking Drugs
- Motor Nicotinic Receptor
- ACh Receptor Agonist
- Depolarization
- Phases of Action
- Phase I (Paralysis Non-reversible)
- Phase II (Paralysis Reversible)
- Neostigmine (Reversal Agent)
2 mins
Indirect Cholinomimetics
- Acetylcholinesterase Inhibitors
- Doesn't Cross BBB
- Edrophonium
- Myasthenia Gravis (Diagnosis)
- Pyridostigmine and Neostigmine
- Myasthenia Gravis (Tx)
- Ileus
- Crosses BBB
- Physostigmine
- Atropine Overdose
- Glaucoma
- Donepezil
- Alzheimer's
2 mins
Fragile X
- Pathophysiology
- Trinucleotide Repeat
- CGG Repeats
- FMR1 Gene
- X-linked Dominant
- Signs and Symptoms
- Developmental Delay
- Autism
- Large Ears
- Large Jaw
- Long Face
- Macroorchidism
2 mins
Circle of Willis
- Characteristics
- Anterior Cerebral Artery (ACA) Supplies Motor/Sensory Parts of the Cortex for Lower Extremities
- Anterior Communicating Artery (Acomm) Connects ACA to ACA
- Internal Carotid Arteries (ICA)
- Middle Cerebral Arteries (MCA) Supply Cortex for Upper Limbs and Face
- Posterior Communicating Artery (Pcomm) Connects ICA to PCA
- Posterior Cerebral Arteries (PCA) Supply Occipital Cortex
- Basilar Artery Supplies Medulla, Pons, and PCA
3 mins
Anterior Cerebral Artery
- Contralateral paralysis of lower limb
- Contralateral loss of sensation in lower limb
1 min
Middle Cerebral Artery
- Contralateral paralysis upper limb and face
- Contralateral loss of sensation of upper limb and face
- Affects Wernicke's area and Broca's area
- Aphasia if Lesion in Dominant (Left) Hemisphere
- Hemineglect if lesion in nondominant (right) hemisphere
1 min
Central Nervous System (CNS)
- Characteristics
- Frontal Lobe
- Parietal Lobe
- Temporal Lobe
- Occipital Lobe
- Medulla Oblongata
- Cerebellum
- Pons
- Spinal Cord
- Dorsal Root Ganglia
- Grey Matter
- White Matter
2 mins
Autonomic Nervous System
- Characteristics
- Sympathetic Nervous System
- Fight or Flight
- All Preganglionic Neurons Release Acetylcholine
- Sympathetic Postganglionic Neurons Release Norepinephrine
- Antagonistic Effects of Sympathetic and Parasympathetic Nervous Systems
- Parasympathetic Nervous System
- Rest and Digest
- Parasympathetic Postganglionic Neurons Release Acetylcholine
2 mins
Neuron Resting Potential
- Characteristics
- More Na+ Outside
- Sodium-Potassium Pump
- K+ Leaks Out
- More K+ Inside
- About -70mV
- Voltage-Gated Sodium Channels are Closed
2 mins
