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Medicine (MD/DO)
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USMLE Step 1
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Neurology, Ophthalmology & Otology
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Neurodegenerative Disorders

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Neurology, Ophthalmology & Otology | Medicine (MD/DO) School Study Aid

Neurodegenerative Disorders
17 Picmonics to Learn | 36 mins
Causes of Dementia
Reversible Causes
Intoxication or Medications
Depression
Normal Pressure Hydrocephalus
Vitamin B12 Deficiency
Metabolic Conditions
Irreversible Causes
Lewy Body Dementia
Prion Disease
Pick's Disease
AIDS Dementia
Alzheimer's Disease
Multi-infarct (Vascular) Dementia
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2 mins
Lewy Body Dementia
Pathophysiology
Unknown Etiology
Decreased Acetylcholine
Alpha-synuclein Defect
Eosinophilic Cytoplasmic Inclusion
Signs and Symptoms
Visual Hallucinations
Progressive Dementia
Fluctuating Cognition
REM Sleep Behavior Disorder
Parkinsonism
Treatment
Acetylcholinesterase Inhibitors
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3 mins
Metachromatic Leukodystrophy
Pathophysiology
Autosomal Recessive
Arylsulfatase A Deficiency
Increased Cerebroside Sulfate
Signs and Symptoms
Demyelination
Ataxia
Dementia
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1 min
Alzheimer's Disease Assessment (Early Symptoms)
Risk Factors
Advanced Age
Early Signs and Symptoms
Poor Judgment and Decision-Making
Difficulty Having a Conversation
Inability to Manage a Budget
Losing Track of the Date or Season
Misplacing Things
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1 min
Alzheimer's Disease Assessment (Late Symptoms)
Late Signs and Symptoms
Memory Impairment
Wandering Behavior
Confabulation
Perseveration
Lack of Abstract Thinking
Severe Cognitive Decline
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1 min
5 A's of Alzheimer's Disease
Agnosia
Anomia
Aphasia
Apraxia
Amnesia
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1 min
Alzheimer's Disease Interventions
Diagnostic Tests
PET Scan and CT
Mini-Mental State Examination
Interventions
Drug Therapy
Safe Environment
Moderate Exercise
Behavioral Modification
Assistance with Functional Independence
Assistance and Support for Caregiver
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2 mins
Parkinson's Disease Assessment
Assessment
Decreased Dopamine
Older Adult
Cogwheel Rigidity
Bradykinesia
Shuffling Gait
Resting Tremor
Pill-Rolling
Mask-Like Face
Cognitive Decline
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2 mins
Parkinson's Disease Interventions
Medications
Levodopa/Carbidopa (Sinemet)
Entacapone (Comtan)
Selegiline (Eldepryl)
Amantadine (Symmetrel)
Bromocriptine (Parlodel)
Benztropine (Cogentin)
Considerations
Allow Extra Time
Ensure Patient Safety
Surgery As Last Resort
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2 mins
Parkinson's Drugs
Parkinsons Characteristics
Decreased Dopamine
Increased Acetylcholine
Drug Names
BALSA Acronym
Bromocriptine
Amantadine
Levodopa
Selegiline
Antimuscarinics
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2 mins
Amyotrophic Lateral Sclerosis (ALS)
Assessment
Progressive Muscle Weakness
Systemic Muscle Wasting
Fasciculations
Spasticity
Fatigue
Considerations
Riluzole (Rilutek)
Stretching
Little to No Cognitive Decline
Respiratory Support
Palliative Care
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2 mins
Huntington's Disease
Pathophysiology
Autosomal Dominant
Trinucleotide Repeat
CAG Repeats
Chromosome 4
Anticipation
Caudate
Decrease of ACh
Decrease of GABA
Signs and Symptoms
Chorea
Dementia
Depression
Glutamate Toxicity
Neuronal Death via NMDA Binding
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3 mins
Normal Pressure Hydrocephalus
Mechanism
Elderly
Idiopathic
Decreased Absorption of CSF
Ventricular Enlargement
Symptom Triad
Urinary Incontinence
Ataxia (Gait)
Cognitive Dysfunction
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2 mins
Kluver-Bucy Syndrome
Bilateral Amygdala Lesion
Associated with HSV-1
Hyperorality
Hypersexuality
Disinhibited Behavior
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1 min
Cerebral Palsy (CP)
Cause/Mechanism
Maternal Infections
Fetal Hypoxia
Assessment
Developmental Delay
Neurological Dysfunction
Spasticity
Dysphagia
Interventions
Muscle Relaxants
Muscle Exercises
Assistive Devices
Braces
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2 mins
Rett Syndrome
Pathogenesis
Sporadic Neurological Disorder
De Novo Mutation of MECP2 on X Chromosome
RISK FACTORS & SYMPTOMS
Seen Almost Exclusively In Girls
Affected Males Die in Utero or Shortly After Birth
Symptoms Usually Appear Between Ages 1-4
Developmental Regression
Motor Impairment
Intellectual Disability (Mental Retardation)
Loss of Verbal Abilities
Seizure
Stereotyped Hand Wringing
Decelerated Head Growth (Microcephaly)
Breathing Problems
Ataxia
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5 mins
Pick's Disease (Frontotemporal Dementia)
Epidemiology
Affects People Aged 45 to 65.
Pathophysiology
Frontal and Temporal Lobes
Occipital and Parietal Lobes are Spared
Tauopathy
Neuronal Apoptosis
Clinical Features
Dementia
Personality Changes, Impaired Judgment, Apathy, and Disinhibition
Behavioral Variant
Primary Progressive Aphasia
Diagnosis Based on Clinical Features and Imaging
Management
Supportive Care
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5 mins

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