Master Antihistone Antibodies with Picmonic for Medicine

The drugs that can result in production of antihistone antibodies can be remembered by the acronym SHIPP: sulfonamides, hydralazine, isoniazid (INH), phenytoin and procainamide. The 3 drugs that are most responsible for produced antihistone antibodies and thus drug-induced lupus are hydrazine, procainamide and INH.

Sulfonamide drugs have been shown to cause development of drug-induced lupus.

This is an antihypertensive drug that is often used in pregnant women with hypertension. It poses a high risk for development of drug-induced lupus.

This is an anti-TB drug that poses a low to moderate risk for development of drug-induced lupus.

This is an anti-seizure drug that poses a low to moderate risk for development of drug-induced lupus.

This is a Class 1A antiarrhythmic drug that poses a high risk for development of drug-induced lupus.