This disease is similar to SLE; however, it is due to certain drugs such as sulfonamides, hydralazine, INH, procainamide and phenytoin (SHIPP) among others. Anti-dsDNA and anti-Smith antibodies are typically absent while anti-histone antibodies are classically present. Treatment involves discontinuing the offending drug and starting the patient on prednisone if needed.
The drugs that can result in production of antihistone antibodies can be remembered by the acronym SHIPP: sulfonamides, hydralazine, isoniazid (INH), phenytoin and procainamide. The 3 drugs that are most responsible for produced antihistone antibodies and thus drug-induced lupus are hydrazine, procainamide and INH.
Sulfonamide drugs have been shown to cause development of drug-induced lupus.
This is an antihypertensive drug that is often used in pregnant women with hypertension. It poses a high risk for development of drug-induced lupus.
This is an anti-TB drug that poses a low to moderate risk for development of drug-induced lupus.
This is an anti-seizure drug that poses a low to moderate risk for development of drug-induced lupus.
This is a Class 1A antiarrhythmic drug that poses a high risk for development of drug-induced lupus.
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