Hypertension Intervention
- Weight Reduction and Exercise
- Diet Changes
- Relaxation Techniques
- Smoking Cessation
- Medications
- Encourage Self Monitoring
Hypertension Medications
- Diuretics
- ACE Inhibitors
- Angiotensin Receptor Blockers (ARBs)
- Beta Blockers
- Dihydropyridine Calcium Channel Blockers
ACE Inhibitors
- -Pril Suffix
- Hypertension
- CHF
- Diabetic Nephropathy
- Inhibits ACE
- Decreases GFR
- Inhibits Constriction of Efferent Arteriole
- Increased Bradykinin
- Cough
ACE Inhibitor Toxicity
- CAPTOPRIL Mnemonic
- Cough
- Angioedema
- Potassium Changes (Hyperkalemia)
- Taste Change
- Hypotension
- Pregnancy Changes
- Rash
- Increased Renin
- Lower Angiotensin II
Angiotensin Receptor Blockers (ARBs)
- -sartan suffix
- Hypertension
- CHF
- Diabetic Nephropathy
- Angiotensin II Receptor Blockers
- Hyperkalemia
- Pregnancy
Calcium Channel Blockers (Verapamil and Diltiazem)
- Slows AV Conduction
- Angina Pectoris
- Arrhythmias
- Essential Hypertension
- Bradycardia
- Hypotension
- Constipation
- Peripheral Edema
- Gingival Hyperplasia
- Medication Education
Loop Diuretics
- Thick Ascending Limb of Loop of Henle
- Inhibits Na+-K+-2Cl- Symporter
- Sulfa Drug
- Furosemide
- Lasix
- Gout
- Ototoxicity
- Hypocalcemia
- Hypokalemia
Ethacrynic Acid
- Non-sulfa Drug
- Phenoxyacetic Acid Derivative
- Loop Diuretic
- Inhibits Na+-K+-2Cl- Cotransporter
- Thick Ascending Loop of Henle
- Diuresis
- Hypokalemia
- Ototoxicity
- Gout
Thiazide Diuretics
- Early Distal Tubule
- Inhibits Na/Cl Reabsorption
- Sulfa Drug
- Hyperglycemia
- Hyperlipidemia
- Hypercalcemia
- Hyperuricemia
- Hyponatremia
- Hypokalemic Metabolic Alkalosis
K+ Sparing Diuretics
- CHF and Hypertension
- Hypokalemia
- Hyperaldosteronism
- Collecting Tubule
- Spironolactone
- Competitive Aldosterone Receptor Antagonist
- Amiloride and Triamterene
- Block Na+ Channels
- Hyperkalemia
- Gynecomastia
Spironolactone (Aldactone)
- Inhibition of Aldosterone
- Potassium Retention
- Hypertension
- Edema
- Heart Failure
- Hyperkalemia
- Endocrine Effects
- Avoid Potassium Supplements
Selective Beta-1 Blockers
- "-olol" Suffix
- Beta-1 Selective
- Atenolol
- Esmolol
- Metoprolol
- Partial Beta agonists
- Acebutolol
Nonselective Beta-Blockers
- "-olol" Suffix
- Nonselective
- Propranolol
- Timolol
- Nadolol
- Partial β Agonist
- Pindolol
- Nonselective β with α Blocking
- Carvedilol
- Labetalol
Systemic Effects of Beta-Blockers
- Respiratory
- Bronchoconstriction
- Metabolic
- Decreased Insulin
- Decreased Glycolysis and Lipolysis
- Eye
- Reduces Intraocular Pressure
Cardiovascular Effects of Beta-Blockers
- Cardiac Myocytes and Vasculature
- Decrease cAMP
- Decreases SA and AV Node Conduction Velocity
- Lower Blood Pressure
- Decrease O2 Consumption
- Decreases Mortality Post-MI
Selective Alpha-1 Blockers
- "-osin" suffix
- Blocks Alpha1 Receptors
- Hypertension
- Benign Prostatic Hyperplasia (BPH)
- Syncope
- Orthostatic Hypotension
Nonselective Alpha-Blockers
- Phentolamine
- Reversible
- Pheochromocytoma (Diagnosis)
- Hypertensive Crisis
- Phenoxybenzamine
- Pheochromocytoma (Treatment)
- Orthostatic Hypotension
- Reflex Tachycardia
Prazosin (Minipress)
- -osin suffix
- Selective Alpha-1 Receptor Blocker
- Hypertension
- Benign Prostatic Hyperplasia (BPH)
- Nightmares
- Orthostatic Hypotension
- Tachycardia
- Priapism / Inhibition of Ejaculation
- Nasal Congestion
- First Dose Effect
- Administer at Bedtime
Minoxidil (Loniten, Rogaine)
- Vasodilates Arterioles
- Severe Hypertension
- Baldness
- Reflex Tachycardia
- Blood Volume Expansion
- Hypertrichosis
- Pericardial Effusion
- Rash
- Give with Beta Blocker and Diuretic
Nitroprusside
- Direct Release of NO
- Increase cGMP
- Short Half-Life
- Malignant Hypertension
- Cyanide Toxicity
Hydralazine
- Reduce Afterload
- Severe Hypertension
- Safe during Pregnancy
- CHF
- Increases cGMP
- Vasodilates Arterioles
- Drug-induced Lupus
- Reflex Tachycardia
Clonidine
- Alpha-2 Agonist
- Hypertensive Urgency
- Attention Deficit Hyperactivity Disorder (ADHD)
- Tourette Syndrome
- Opioid Withdrawal
- CNS Depression
- Respiratory Depression
- Hypotension
- Rebound Hypertension if Abrupt Cessation