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Pathology | Medicine (MD/DO) School Study Aid
Primary Myelofibrosis
- Characteristics
- Bone Marrow Fibrosis
- Extramedullary Hematopoiesis
- JAK2 Kinase Mutation
- Symptoms
- Fatigue
- Weight Loss
- Splenomegaly
- DIagnosis
- Pancytopenia
- Dacrocytes (Teardrop Cells)
- Dry Tap on Bone Marrow Aspiration
- Treatment
- Stem Cell Transplantation
- Transfusion
- Ruxolitinib (JAK2 Inhibitor)
2 mins
Tumor Lysis Syndrome
- Characteristics
- Leukemia/Lymphoma Treatment
- Oncologic Emergency
- Clinical Features
- GI Distress
- Fatigue
- Arrhythmias
- Acute Kidney Injury
- Lab Findings
- Hyperkalemia
- Hyperphosphatemia
- Hyperuricemia
- Hypocalcemia
- Management
- Aggressive Hydration
- Electrolyte Correction
- Allopurinol
- Rasburicase
3 mins
Snake Bite Injury
- Local Findings
- Edema
- Erythema
- Tissue Necrosis
- Systemic Findings
- Neurotoxicity
- Distributive Shock
- Disseminated Intravascular Coagulation (DIC)
- Diagnosis
- Diagnosis by Clinical Impression
- Management
- Antivenom
- Closely Monitor Patient
2 mins
Langerhans Cell Histiocytosis
- Characteristics
- Antigen Presentation Defect
- Lytic Bone Lesions
- Skull
- Presentation
- Hypopituitarism
- Diabetes Insipidus
- Skin Rash
- Recurrent Otitis Media
- Diagnosis
- Birbeck Granules
- "Tennis Racket" Appearance
- S100 Positive
- Management
- Observation
- Prednisone +/- Vinblastine
4 mins
Hemophagocytic Lymphohistiocytosis
- Characteristics
- Excessive Immune System Activation
- Cytotoxic T-cells and Macrophages
- Cytokine Storm
- Acquired or Sporadic
- Presentation
- Fever
- Hepatosplenomegaly
- Labs
- Increased Ferritin
- Pancytopenia
- Management
- Bone Marrow Transplantation
3 mins
Essential Thrombocythemia
- Characteristics
- JAK2 Mutation
- Presentation
- Often Asymptomatic
- Thromboembolic Events
- Spontaneous Abortion
- Erythromelalgia
- Gout
- Diagnosis
- Thrombocytosis
- Megakaryocyte Hyperplasia
- Management
- Aspirin
- Hydroxyurea
2 mins
Myelodysplastic Syndromes
- Characteristics
- Dysfunctional Bone Marrow
- Elderly
- Radiation or Chemotherapy
- Presentation
- Anemia
- Increased Susceptibility to Infection
- Bleeding
- Diagnosis
- Ringed Sideroblasts
- Howell-Jolly Bodies
- Pseudo-Pelger-Huet Anomaly
- Bilobed Neutrophils
- Management
- Supportive Care
- Bone Marrow Transplant
- Considerations
- Acute Myelogenous Leukemia (AML)
4 mins
Methemoglobinemia Characteristics
- Characteristics
- Oxidized Iron in Hemoglobin
- Decreased Affinity for Oxygen
- Increased Affinity for Cyanide
- Etiologies
- Dietary Nitrates
- Drugs
- Nitroglycerin
- Lidocaine
- G6PD Deficiency
2 mins
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