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Pediatrics | Medicine (MD/DO) School Study Aid
Hyperbilirubinemia
- Cause/Mechanism
- Increased Unconjugated Bilirubin
- Assessment
- Jaundice
- Kernicterus
- Interventions
- Early Feedings
- Heme Oxygenase Inhibitors
- Phototherapy
- Protect Eyes
- Monitor for Dehydration
- Considerations
- Monitor Bilirubin Levels
3 mins
Beta Thalassemia
- Mechanism
- Microcytic, Hypochromic Anemia
- Mediterranean Populations
- Decreased Beta-Globin
- Beta-Thalassemia Minor
- Increased HbA2
- No Intervention
- Beta-thalassemia Major
- Blood Transfusions
- Hemochromatosis
- Crew-cut on Skull X-Ray
- Diagnosis
- Electrophoresis
2 mins
Sickle Cell Anemia (Mechanism)
- Intrinsic Normocytic Hemolytic Anemia
- Point Mutation
- Autosomal Recessive
- African American
- Dehydration or Decreased O2
- Newborns Asymptomatic
- Heterozygote Malarial Resistance
2 mins
Sickle Cell Anemia (Signs and Complications)
- Signs
- Crew-cut on Skull X-ray
- Complications
- Auto-splenectomy
- Painful Crisis
- Aplastic Crisis
- Splenic-sequestration Crisis
- Hyper-hemolytic Syndrome
- Renal Papillary Necrosis
- Salmonella osteomyelitis
- Pulmonary Hypertension
- Hyposthenuria
2 mins
Sickle Cell Anemia (Management)
- Long Term Treatment
- Hydroxyurea
- Bone Marrow Transplant
- Folate
- Acute Treatment
- Exchange Transfusion
- Prophylaxis
- Penicillin Prophylaxis
1 min
Hemolytic Uremic Syndrome (HUS)
- Children
- Pathophysiology
- Preceded by Acute Diarrheal Illness
- Endothelial Damage
- Classic Triad of Symptoms
- Microangiopathic Hemolytic Anemia (MAHA)
- Thrombocytopenia
- Renal Failure
- Labs
- Helmet cells
- LDH
- Treatment
- Dialysis
- Supportive
2 mins
Hereditary Spherocytosis Disease
- Northern Europeans
- Mechanisms
- Autosomal Dominant
- Spectrin/Ankyrin Deficiency
- Spherocyte Formation
- Hemolytic Anemia
- Symptoms
- Bilirubin Gallstones
- Jaundice
- Splenomegaly
3 mins
Hereditary Spherocytosis Diagnosis & Treatment
- Labs
- Increased MCHC
- Spherocytes
- Normocytic Anemia
- Diagnosis
- Eosin-5-Maleimide (EMA) Binding Test
- Osmotic Fragility Test
- Glycerol Lysis Test
- Treatment
- Folic Acid
- Splenectomy
2 mins
Fanconi Anemia
- Characteristics
- Autosomal Recessive
- Aplastic Anemia
- DNA Crosslink Repair Defect
- Clinical Presentation
- Short Stature
- Microcephaly
- Thumb and Forearm Malformations
- Cafe Au Lait Spots
- Ocular Abnormalities
- Horseshoe Kidney
- Lab Findings
- Chromosomal Breakage Testing
- Macrocytic Anemia
- Pancytopenia
- Management
- Monitor For Malignancy and Bone Marrow Failure
- Hematopoietic Stem Cell Transplantation
3 mins
Enterohemorrhagic E. Coli (EHEC)
- Characteristics
- O157:H7
- Non-Sorbitol Fermenting
- Hamburger Meat
- Produces Shiga-like Toxin
- Gram-negative
- Lysogeny
- Inactivates 60S Ribosome
- Disease
- Bloody Diarrhea
- Hemolytic Uremic Syndrome (HUS)
- Hemolytic Anemia
- Acute Renal Failure
- Thrombocytopenia
2 mins
ABO Hemolytic Disease of the Fetus and Newborn
- Characteristics
- ABO Incompatibilities
- Type O Mother and Type A/B Fetus
- Anti-A or Anti-B Antibodies
- Hemolytic Anemia
- Presentation
- Often Asymptomatic
- Neonatal Jaundice
- Diagnosis
- Negative Coombs Test
- Management
- Phototherapy
2 mins
Rh Hemolytic Disease of the Fetus and Newborn
- Characteristics
- Rh (Rhesus) Incompatibilities
- Rh(D)- Mother and Rh(D)+ Fetus
- Anti-Rh(D) Antibodies
- Hemolytic Anemia
- Presentation
- Hydrops Fetalis
- Neonatal Jaundice
- Kernicterus
- Diagnosis
- Positive Coombs Test
- Ultrasound
- Management
- RhoGAM [Anti-Rh(D) Immunoglobulin]
- Intrauterine Blood Transfusion
- Phototherapy
- IVIG (Intravenous Immunoglobulin)
4 mins
Langerhans Cell Histiocytosis
- Characteristics
- Antigen Presentation Defect
- Lytic Bone Lesions
- Skull
- Presentation
- Hypopituitarism
- Diabetes Insipidus
- Skin Rash
- Recurrent Otitis Media
- Diagnosis
- Birbeck Granules
- "Tennis Racket" Appearance
- S100 Positive
- Management
- Observation
- Prednisone +/- Vinblastine
4 mins
Hemophagocytic Lymphohistiocytosis
- Characteristics
- Excessive Immune System Activation
- Cytotoxic T-cells and Macrophages
- Cytokine Storm
- Acquired or Sporadic
- Presentation
- Fever
- Hepatosplenomegaly
- Labs
- Increased Ferritin
- Pancytopenia
- Management
- Bone Marrow Transplantation
3 mins
Diamond-Blackfan Anemia
- Characteristics
- Red Blood Cell Aplasia
- Macrocytic Anemia
- Clinical Features
- Short Stature
- Craniofacial Anomalies
- Triphalangeal Thumbs
- Diagnosis
- Increased HbF (Fetal Hemoglobin)
- Management
- RBC Transfusion
- Steroids
- Hematopoietic Stem Cell Transplantation
2 mins
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