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First Aid for the USMLE Step 1 (2018) | Medicine (MD/DO) School Study Aid
Eukaryotic Post Transcriptional Modification
- Modifications in Nucleus
- mRNA Splicing
- Introns Cut Out
- Exons spliced together
- Alternate Splicing
- 5' Cap added
- 3' Poly A tail added
- Transported to Cytosol
2 mins
Translation: Initiation
- Translation: Initiation
- Ribosome Binds mRNA
- Complex Reads 5' to 3'
- AUG Start Codon
- Initiation Complex Forms
- GTP and Initiation Factor Bring Complex Together
- Met-tRNA Binds P Site
- tRNA With Bound Amino Acids Binds A Site
- Amino Acid Chain Created in Elongation
3 mins
Translation: Elongation & Termination
- Translation: Elongation
- Amino Acid Chain Is Created
- New Amino Acid-tRNA Enters A Site
- GTP and Elongation Factors Help tRNA Enter A Site
- Peptide Chain Binds to New Amino Acid
- Peptide Chain-tRNA Moves to P Site
- Free tRNA in P Site Moves to E Site
- Translation: Termination
- Stop Codon at A Site Causes Termination
- Release Factors Help Complex Disassociate
- Complex Falls Apart
3 mins
