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First Aid
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First Aid for the USMLE Step 1 (2021)
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First Aid for the USMLE Step 1 (2021) | Medicine (MD/DO) School Study Aid

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4 Picmonics to Learn | 8 mins
Digoxin Mechanism and Indication
Direct inhibition of Na K ATPase
Indirect inhibition of Na Ca exchanger
Increase Ca in cell
Positive Inotropy
CHF
Stimulates Vagus Nerve
Decreased conduction at AV node
Atrial Fibrillation
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1 min
Acute Digoxin Toxicity
Clinical Symptoms
Hyperkalemia
Cholinergic (Nausea, Vomiting, Diarrhea)
Blurry Yellow Green Vision with Halo of Light
Arrhythmia
Bradycardia
EKG Changes
Prolonged PR interval
Decreased QT
Scooping on EKG
T Wave Inversion
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2 mins
Digoxin Toxicity Treatment
Activated Charcoal
Slowly Normalize K+
Digibind (Anti-Digoxin Fab)
Magnesium Sulfate
Lidocaine
Cardiac Pacing
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2 mins
PCSK9-Inhibitors
AVAILABLE DRUGS
Evolocumab
Alirocumab
MECHANISM OF ACTION
Monoclonal Antibodies
Bind the PCSK9 Enzyme
Decreased Degradation of LDL-receptors
Increased LDL Receptors on Hepatocytes
Reduction of LDL in Plasma
INDICATION
Second-line Therapy for Hypercholesterolemia
ADMINISTRATION
Subcutaneous Injection
SIDE EFFECTS
Skin Reaction at the Injection Site
Myalgia
Neurocognitive Impairment
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2 mins

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