Gardner Syndrome
- Familial Adenomatous Polyposis (FAP) + Extraintestinal Benign Tumors
- Autosomal Dominant
- APC Gene Mutation
- Desmoid Tumors
- Nasal Angiofibromas
- Osteomas
- Congenital Hypertrophy of Retinal Pigment Epithelium
- Dental Abnormalities
- Cutaneous Lesions
- Adrenal Adenomas
- Thyroid Cancer
- Duodenal / Periampullary Cancer
- Pancreatic Cancer
- Hepatoblastoma
Turcot Syndrome
- Autosomal Dominant or Autosomal Recessive
- Colonic Polyposis + CNS Tumor
- Increased Risk of Colorectal Cancer
- Increased Risk of Brain Cancer
- Lynch Syndrome
- Glioblastoma Multiforme
- Familial Adenomatous Polyposis (FAP)
- Medulloblastoma
Peutz-Jeghers Syndrome
- Symptomatic Age: 10-30 Years
- LKB1/STK11 Gene Mutation
- Autosomal Dominant
- Benign GI Hamartomatous Polyps
- Mucocutaneous Hyperpigmentation
- Positive Family History
- Increased Risk of Colorectal Carcinoma
Familial Adenomatous Polyposis
- Autosomal Dominant
- Mutation in Chromosome 5
- APC Gene Mutation
- Overexpression of Beta-catenin
- Two-Hit Hypothesis
- Change in Bowel Habits
- Colonic Polyps
- Colonoscopy
- Prophylactic Surgery
- Progresses to Colorectal Carcinoma
Juvenile Polyposis Syndrome
- Autosomal Dominant
- Children < 5 Years Old
- Hamartomatous Polyps in Gastrointestinal Tract
- GI Distress
- Anemia
- Increased Risk of Colorectal Carcinoma
Non-neoplastic Colonic Polyps
- Benign
- Hyperplastic Polyps
- Rectosigmoid
- Hamartomatous Polyps
- Peutz-Jeghers Syndrome
- Juvenile Polyposis Syndrome
- Inflammatory Pseudopolyps
- Inflammatory Bowel Disease
- Mucosal Polyps
- Submucosal Polyps
Neoplastic Colonic Polyps
- Malignant
- Adenomatous Polyps
- APC and KRAS Mutation
- Villous Type is more Malignant
- Serrated Polyps
- BRAF Mutation
- Saw-Tooth Pattern