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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 1 (2023)
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First Aid for the USMLE Step 1 (2023) | Medicine (MD/DO) School Study Aid

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3 Picmonics to Learn | 10 mins
Glycolysis
Characteristics
Glucose
Hexokinase or Glucokinase
Glucose-6-phosphate
Fructose-6-phosphate
Phosphofructokinase-1 (PFK-1)
Fructose-1,6-bisphosphate
Aldolase
Glyceraldehyde-3-Phosphate
1,3-bisphosphoglycerate
3-phosphoglycerate
2-phosphoglycerate
Phosphoenolpyruvate (PEP)
Pyruvate Kinase
Pyruvate
Pyruvate Dehydrogenase
Acetyl-CoA
picmonic thumbnail
4 mins
Gluconeogenesis
OVERVIEW
Produces Glucose from Non-Carbohydrate Substrates
Upregulated by Glucagon and Cortisol
PATHWAY
Pyruvate
Pyruvate Carboxylase
Oxaloacetate
Phosphoenolpyruvate (PEP) Carboxykinase
Phosphoenolpyruvate (PEP)
Fructose-1,6-bisphosphate
Fructose-1,6-bisphosphatase
Fructose-6-phosphate
Glucose-6-phosphate
Glucose 6-phosphatase
Glucose
Clinical Relevance
Von Gierke Disease
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4 mins
Fed State Metabolism
Increased Insulin
Decreased cAMP
Decreased Protein Kinase A
Decreased Fructose Bisphosphatase-2
Increased Phosphofructokinase-2
Increased Glycolysis
Decreased Gluconeogenesis
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1 min

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