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First Aid
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First Aid for the USMLE Step 1 (2023)
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First Aid for the USMLE Step 1 (2023) | Medicine (MD/DO) School Study Aid

Page 325 -
4 Picmonics to Learn | 8 mins
Fibrates
Indications
Hyperlipidemia
Mechanism of Action
Upregulate LPL
Decreases Triglycerides
Slight Increase in HDL
Slight Decrease in LDL
Side Effect
Hepatotoxicity
Cholesterol Gallstones
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1 min
Niacin Therapy (Vitamin B3)
Mechanism
Inhibits Lipolysis in Adipose Tissue
Reduces Hepatic VLDL Secretion
Indications
Decrease Triglycerides
Decrease LDL
Increase HDL
Side Effects
Flushing
Decreased by Aspirin
Hyperglycemia
Hyperuricemia
picmonic thumbnail
2 mins
Hypercholesterolemia Treatment
Lifestyle Modifications (Diet, Exercise, Smoking Cessation)
Statins
Niacin
Ezetimibe
Fibrates
Bile Acid Resins
PCSK9 Inhibitors
Omega 3 Fatty Acids
Screening
Pooled Cohort Test
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2 mins
PCSK9-Inhibitors
AVAILABLE DRUGS
Evolocumab
Alirocumab
MECHANISM OF ACTION
Monoclonal Antibodies
Bind the PCSK9 Enzyme
Decreased Degradation of LDL-receptors
Increased LDL Receptors on Hepatocytes
Reduction of LDL in Plasma
INDICATION
Second-line Therapy for Hypercholesterolemia
ADMINISTRATION
Subcutaneous Injection
SIDE EFFECTS
Skin Reaction at the Injection Site
Myalgia
Neurocognitive Impairment
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2 mins

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