Master Mesocortical Pathway (Dopaminergic) with Picmonic for Medicine

The mesocortical pathway begins in the ventral tegmental area (VTA) of the midbrain and extends to the prefrontal cortex of the frontal lobe.

The mesocortical pathway begins in the ventral tegmental area (VTA) of the midbrain and extends to the prefrontal cortex of the frontal lobe.

The mesocortical pathway is known to control the executive functioning of the brain. This functioning can involve planning, cognition, attention, motivation, and emotional response.

An inhibition or defect of the mesocortical pathway leads to the presentation of negative symptoms (e.g., lack of energy, flat affect, anhedonia, apathy) often seen in those with schizophrenia.

Overall, the mesocortical pathway has limited efficacy in terms of responding to antipsychotics.