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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 2 CK (10th Ed.)
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Acute Kidney Injury

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First Aid for the USMLE Step 2 CK (10th Ed.) | Medicine (MD/DO) School Study Aid

Acute Kidney Injury
6 Picmonics to Learn | 16 mins
Prerenal Acute Kidney Injury Pathophysiology and Presentation
Pathophysiology
Decreased Renal Perfusion
Decreased GFR
Increased Sodium and Water Reabsorption
Presentation
Edema
Dyspnea
Hypotension with Tachycardia
Altered Mental Status
Oliguria
Etiologies
NSAIDs
Renal Artery Stenosis
ACE Inhibitors
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2 mins
Prerenal Acute Kidney Injury Diagnosis and Management
Diagnostic Findings
BUN:Creatinine Ratio > 20:1
Fractional Excretion of Sodium (FENa) < 1%
Urine Osmolality > 500 mOsm/kg
Hyaline Casts
Management
Fluid Replacement
Monitor Renal Function
Diuretics
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2 mins
Acute Tubular Necrosis
ETIOLOGY
Ischemic Injury
Nephrotoxic Injury
HISTOLOGY
Granular Muddy Brown Casts
Signs & Symptoms
Intrinsic Renal Failure
Oliguric Phase
Metabolic Acidosis
Hyperkalemia
Increase in BUN and Creatinine
Polyuria Phase
Decrease in BUN and Creatinine
Hypokalemia
Treatment
Supportive Care
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3 mins
Postrenal Acute Kidney Injury Pathophysiology and Presentation
Pathophysiology
Bilateral Outflow Obstruction
Decreased GFR
Etiologies
Benign Prostatic Hyperplasia (BPH)
Nephrolithiasis
Neoplasm
Neurogenic Bladder
Presentation
Bladder Distension
Lower Abdominal Pain
Edema
Oliguria
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3 mins
Post Renal Acute Kidney Injury (AKI) Diagnosis and Management
Diagnosis
Physical Examination
BUN:Creatinine ratio of 20:1 in the Initial Stages
BUN:Creatinine ratio of 10:1 in the late stages
Urine Osmolality <350 mOsm/kg
Variable Fractional Excretion of Sodium (FENa)
Ultrasound
CT Scan
Management
Treat Underlying Cause
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4 mins
Intrinsic Renal Failure
Etiologies
Acute Tubular Necrosis
Acute Interstitial Nephritis
Vasculitis
Malignant Hypertension
Acute Glomerulonephritis
TTP-HUS
Diagnosis
Fractional Excretion of Sodium (FENa) > 2%
Urine Osmolality < 350 mOsm/kg
Urine Na+ >40 mEg/L
Serum BUN/Cr < 15
Treatment
Treat Underlying Disorder
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2 mins

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