NNRTI Drug Names
- Nevirapine (Viramune)
- Rilpivirine (Edurant)
- Delavirdine (DLV, Rescriptor)
- Efavirenz (EFV, Sustiva)
- Etravirine (ETR, Intelence)
NRTI Toxicity
- Bone Marrow Suppression
- Reverse with G-CSF and Erythropoietin
- Rash
- Neuropathy
- Anemia
- Pancreatitis
- Lactic Acidosis
Azoles (Ketoconazole)
- "-azole" suffix
- Local and Less Serious Systemic Mycosis
- Inhibits Ergosterol Synthesis
- Inhibits P450
- Liver Dysfunction
- Inhibition of Testosterone Synthesis
Amphotericin B
- Systemic Mycosis
- Fungal Meningitis
- Last Resort for Protozoan infections
- Polyene
- Binds Ergosterol
- Forms Membrane Pores
Amphotericin B Side Effects & Toxicity
- Fever/Chills "Shake and Bake"
- Nephrotoxicity
- Milder with Liposomes
- Hypotension
- Anemia
- IV Phlebitis
- Arrhythmias
Tacrolimus (Prograf) Overview
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Transplant Rejection
- Atopic Dermatitis
- Increased Lymphoma Risk
- Avoid Grapefruit Juice
Tacrolimus (Prograf) Side Effects
- Nephrotoxicity
- Neurotoxicity
- GI Distress
- Infection
- Hypertension
- Hyperkalemia
- Hyperglycemia
Methotrexate
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
RhoGam [Rho(D) Immune Globulin]
- Antepartum Prevention at 28 weeks
- Suppress Antibody Production
- Lysis of Fetal RBC in Maternal Bloodstream
- Myalgia and Lethargy
- Negative Coombs Test
- Standard Dose 300 mcg
- Microdose 50 mcg
- Blood Product
Cyclosporine (Sandimmune) Overview
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Prevent Transplant Rejection
- Psoriasis
- Rheumatoid Arthritis
- Monitor Plasma Levels
- Avoid Grapefruit Juice
- Increased Risk of Lymphoma
Cyclosporine (Sandimmune) Side Effects
- Nephrotoxicity
- Hepatotoxicity
- Infection
- Hypertension
- Hirsutism
- Tremor
- Hyperkalemia
- Hypomagnesemia
- Gingival Hyperplasia
Aminoglycoside Overview
- End in "-mycin"
- Gentamicin
- Neomycin
- Amikacin
- Tobramycin
- Streptomycin
- Bactericidal
- Severe Gram Negative Infections
- Bowel Surgery Prep
Aminoglycoside Side Effects
- Ototoxicity
- Nephrotoxicity
- Respiratory Paralysis
- Pregnancy
- Peak and Trough
- Never Mix with Penicillin in Same IV
Cephalosporins
- Starts with "Cef-"
- Bactericidal
- Gram-Positive and Gram-Negative Infections
- Allergic Reactions
- Thrombophlebitis
- Bleeding
- Renal Impairment
- Avoid IV Calcium with Ceftriaxone
- No Alcohol
Fluoroquinolones
- End in "-floxacin"
- Bactericidal
- Variety of Infections
- GI Distress
- Photosensitivity
- Achilles Tendon Rupture
- Pregnancy
- Children
- Myasthenia Gravis
- Avoid Milk Products or Antacids
- Slow IV Infusion
Fluoroquinolones Toxicities
- Diarrhea
- Skin Rash
- Headache
- Tendon Rupture in Adults
- Myalgias in Kids
- Damage to Cartilage
- Teratogen
- QT Prolongation
Macrolides
- Bacteriostatic
- Bind to 23S rRNA of 50S Subunit
- Inhibit Protein Synthesis by Blocking Translocation
- Erythromycin
- Azithromycin
- Clarithromycin
- Gram-Positive Cocci
- Atypical Pneumonia
- Chlamydia
- Resistance by Methylation of 23S rRNA Binding
Penicillin
- Weakens Cell Wall
- Gram-Positive Infections
- Prophylaxis
- Pain at IM Injection Site
- Allergic Reaction
- Skin Tests
- Allergy ID
- Medication Education
Ampicillin and Amoxicillin
- Aminopenicillin
- Broad Spectrum Penicillin
- Gram-Positive and Some Gram-Negative Infections
- Rash
- Diarrhea
- No Effect Against Staph Aureus
- Often combined with Beta Lactamase Inhibitor
- Allergic Reaction
Sulfonamides
- Bacteriostatic
- Urinary Tract Infection
- Crystalluria
- Photosensitivity
- Hemolytic Anemia
- Kernicterus
- Rash
- Sulfa Allergy
- Encourage Fluids
Sulfonamides Side Effects
- Hypersensitivity
- Nephrotoxicity
- Photosensitivity
- Kernicterus in Infants
- Displaces Warfarin from Albumin
- Hemolysis with G6PD Deficiency
Tetracyclines Overview
- End in "-cycline"
- Bacteriostatic
- Infectious Diseases
- Acne
- Periodontal Disease
- Avoid Milk, Antacids, Iron
- Sunlight Protection
Tetracyclines Side Effects
- Superinfection
- Clostridioides difficile
- Discoloration of Teeth
- Bone Deformities
- Photosensitivity
- Children Under 8
- Pregnancy
Acyclovir (Zovirax)
- Guanosine Analog
- Inhibits Viral Replication
- Thymidine Kinase Activation
- Herpes Simplex Virus (HSV)
- Varicella Zoster Virus (VZV)
- Headache
- GI Distress
- CNS Toxicity
- Nephrotoxicity (Crystalline Nephropathy)
- Prevents Recurrent Episodes
- Slow IV Infusion
Ganciclovir
- Cytomegalovirus (CMV)
- Immunocompromised
- Guanosine Analog
- Disrupts DNA Synthesis
- Inhibits Viral DNA Polymerase
- Hematologic Effects
- Nephrotoxicity