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Pharmacology | Pharmacist (Pharm.D) School Study Aid
Digoxin Mechanism and Indication
- Direct inhibition of Na K ATPase
- Indirect inhibition of Na Ca exchanger
- Increase Ca in cell
- Positive Inotropy
- CHF
- Stimulates Vagus Nerve
- Decreased conduction at AV node
- Atrial Fibrillation
1 min
Acute Digoxin Toxicity
- Clinical Symptoms
- Hyperkalemia
- Cholinergic (Nausea, Vomiting, Diarrhea)
- Blurry Yellow Green Vision with Halo of Light
- Arrhythmia
- Bradycardia
- EKG Changes
- Prolonged PR interval
- Decreased QT
- Scooping on EKG
- T Wave Inversion
2 mins
Digoxin Toxicity Treatment
- Activated Charcoal
- Slowly Normalize K+
- Digibind (Anti-Digoxin Fab)
- Magnesium Sulfate
- Lidocaine
- Cardiac Pacing
2 mins
Beta-1 Agonists
- Dobutamine
- Heart Failure
- Cardiac Stress Test
- Isoproterenol
- Bradyarrhythmias
- Torsades de Pointes
58 secs
Dobutamine
- Mechanism
- Beta-1 Agonist
- Inotropic
- Indications
- Heart Failure
- Side Effects
- Tachycardia
- Arrhythmias
- Considerations
- Closely Monitor Patients
- Other Meds May Increase Potency
1 min
Milrinone and Amrinone
- Mechanism of Action
- Phosphodiesterase 3 Inhibitor
- Potentiates Beta Receptor Effects
- Inotrope
- Vasodilator
- Indication
- Acute Decompensated Heart Failure
- Side Effects
- Ventricular Arrhythmias
- Hypotension
2 mins
Cilostazol and Dipyridamole
- Mechanism of Action
- Phosphodiesterase 3 Inhibitor (PDE-3)
- Inhibits Platelet Aggregation
- Vasodilation
- Indications
- Intermittent Claudication
- Stroke Prevention
- Coronary Stent Stenosis Prevention
- Cardiac Stress Testing (Dipyridamole)
- Side Effects
- Flushing
- Hypotension
3 mins
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