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Physician Assistant (PA)
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First Aid for the USMLE Step 1 (2021)
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First Aid for the USMLE Step 1 (2021) | Physician Assistant (PA) School Study Aid

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3 Picmonics to Learn | 9 mins
Cyanide Poisoning: Pathophysiology and Clinical Manifestation
Pathophysiology
Inhibits Complex IV of Oxidative Phosphorylation
Forces Cells Into Anaerobic Metabolism
Presentation
Exposure to Fire Fumes
Industrial Exposure
Headache and Confusion
Arrhythmias
"Cherry Red" Skin
Almond Breath/Taste
Acute Renal Failure
picmonic thumbnail
4 mins
Cyanide Poisoning Diagnosis and Treatment
Lab Findings
Lactic Acidosis
Elevated Venous PO2
Check Carboxyhemoglobin
Management
Sodium Nitrate PLUS Sodium Thiosulfate
Methemoglobinemia
OR Hydroxocobalamin (First Line)
picmonic thumbnail
4 mins
Nitroprusside
Mechanism of Action
Direct Release of NO
Increase cGMP
Short Half-Life
Indications
Malignant Hypertension
Side Effect
Cyanide Toxicity
picmonic thumbnail
1 min

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