Class IV Antiarrhythmics (Ca2+ Channel Blockers)
- SVT
- Subarachnoid Hemorrhage
- Decrease Conduction Velocity
- Increase PR Interval and ERP
- Verapamil
- Diltiazem
- Nimodipine
- Cardiovascular
- Constipation
Calcium Channel Blockers (Verapamil and Diltiazem)
- Slows AV Conduction
- Angina Pectoris
- Arrhythmias
- Essential Hypertension
- Bradycardia
- Hypotension
- Constipation
- Peripheral Edema
- Gingival Hyperplasia
- Medication Education
Hydralazine
- Reduce Afterload
- Severe Hypertension
- Safe during Pregnancy
- CHF
- Increases cGMP
- Vasodilates Arterioles
- Drug-induced Lupus
- Reflex Tachycardia
Minoxidil (Loniten, Rogaine)
- Vasodilates Arterioles
- Severe Hypertension
- Baldness
- Reflex Tachycardia
- Blood Volume Expansion
- Hypertrichosis
- Pericardial Effusion
- Rash
- Give with Beta Blocker and Diuretic
Alpha-2 Agonists (Sympathoplegics)
- Hypertension
- Renal disease
- Centrally acting Alpha-2 Agonist
- Clonidine
- Rebound Hypertension
- Alpha-Methyldopa
- Pregnancy
- Coombs (+) Hemolytic Anemia
- SLE Like Syndrome
Class I Antiarrhythmics (Na+ Channel Blockers) Overview
- Arrhythmias
- Local Anesthesia
- Block or Slow Conduction
- Block Na+ Channels
- Raise Threshold
- State Dependent
- Hyperkalemia
Class IA Antiarrhythmics (Na+ Channel Blockers)
- Arrhythmias
- Increase AP, ERP, and QT interval.
- Disopyramide
- Procainamide
- Drug-induced Lupus
- Quinidine
- Cinchonism
- Thrombocytopenia
- Torsades de Pointes
Class IB Antiarrhythmics (Na+ Channel Blockers)
- Arrhythmias
- After Myocardial Infarction
- Affect Ischemic Tissue
- Decrease AP duration
- Mexiletine
- GI Upset
- Lidocaine
- CNS Depression
- Tocainide
- Phenytoin
- Hirsutism
Class IC Antiarrhythmics (Na+ Channel Blockers)
- Used as Last Resort
- V-Tach
- No Effect on AP Duration
- Propafenone
- Flecainide
- Post-Myocardial Infarction
Class III Antiarrhythmics (K+ Channel Blockers)
- Arrhythmias
- Increase AP Duration, ERP, and QT Interval
- Amiodarone
- Check Function Tests
- Dirty Drug
- Ibutilide
- Dofetilide
- Sotalol
- Beta-Blocker