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PANCE Prep Pearls: 3rd Ed. (2019) | Physician Assistant (PA) School Study Aid
Huntington's Disease
- Pathophysiology
- Autosomal Dominant
- Trinucleotide Repeat
- CAG Repeats
- Chromosome 4
- Anticipation
- Caudate
- Decrease of ACh
- Decrease of GABA
- Signs and Symptoms
- Chorea
- Dementia
- Depression
- Glutamate Toxicity
- Neuronal Death via NMDA Binding
3 mins
Essential Tremor
- Characteristics
- Most Common Tremor in Adults
- Positive Family History
- Clinical Findings
- Bilateral Upper Extremities
- Worse with Physical and Psychological Stress
- Better with Rest and Alcohol
- Management
- Beta Blockers
- Primidone
1 min
Parkinson's Disease Assessment
- Assessment
- Decreased Dopamine
- Older Adult
- Cogwheel Rigidity
- Bradykinesia
- Shuffling Gait
- Resting Tremor
- Pill-Rolling
- Mask-Like Face
- Cognitive Decline
2 mins
Parkinson's Disease Interventions
- Medications
- Levodopa/Carbidopa (Sinemet)
- Entacapone (Comtan)
- Selegiline (Eldepryl)
- Amantadine (Symmetrel)
- Bromocriptine (Parlodel)
- Benztropine (Cogentin)
- Considerations
- Allow Extra Time
- Ensure Patient Safety
- Surgery As Last Resort
2 mins
Parkinson's Drugs
- Parkinsons Characteristics
- Decreased Dopamine
- Increased Acetylcholine
- Drug Names
- BALSA Acronym
- Bromocriptine
- Amantadine
- Levodopa
- Selegiline
- Antimuscarinics
2 mins
Levodopa/Carbidopa (Sinemet)
- Indications
- Parkinson's Disease
- Mechanism of Action
- Increase Dopamine in Brain
- Cross blood-brain barrier
- Increase bioavailability
- Side Effects
- Arrhythmias
- Dyskinesia
1 min
Monoamine Oxidase Inhibitors (MAO-Is)
- Indications
- Atypical Depression
- Mechanism of Action
- Increase Levels of Amine Neurotransmitters
- Drugs
- "Takes Pride In Shanghai"
- Tranylcypromine
- Phenelzine
- Isocarboxazid
- Selegiline
1 min
Amyotrophic Lateral Sclerosis (ALS)
- Assessment
- Progressive Muscle Weakness
- Systemic Muscle Wasting
- Fasciculations
- Spasticity
- Fatigue
- Considerations
- Riluzole (Rilutek)
- Stretching
- Little to No Cognitive Decline
- Respiratory Support
- Palliative Care
2 mins
Tourette Syndrome
- Characteristics
- Motor and Vocal Tics
- Onset Before Age 18
- > 1 year
- Associations
- Obsessive-Compulsive Disorder (OCD)
- Attention Deficit Hyperactivity Disorder (ADHD)
- TREATMENT
- Cognitive Behavioral Therapy
- High-Potency Antipsychotics
- Atypical Antipsychotics
- Alpha-2 Agonists
- Tetrabenazine
4 mins
Cerebral Palsy (CP)
- Cause/Mechanism
- Maternal Infections
- Fetal Hypoxia
- Assessment
- Developmental Delay
- Neurological Dysfunction
- Spasticity
- Dysphagia
- Interventions
- Muscle Relaxants
- Muscle Exercises
- Assistive Devices
- Braces
2 mins
Restless Legs Syndrome
- Pathophysiology
- Idiopathic
- Iron Deficiency
- Parkinson's Disease
- Signs and Symptoms
- Urge to Move the Legs
- Unpleasant Sensations in Legs
- Worsens with Inactivity
- Relieved by Movement
- Treatment
- Iron Supplementation
- Self-care
- Gabapentin
- Pramipexole
2 mins
Facial Nerve Lesions
- Etiology
- Diabetes Mellitus
- Sarcoidosis
- Tumors
- Herpes Simplex Virus (HSV)
- Bell's palsy
- Varicella Zoster Virus (VZV)
- Lyme Disease
- Treatment
- Corticosteroids
- Acyclovir
2 mins
Guillain-Barre Syndrome Assessment
- Assessment
- Ascending Paralysis
- Muscle Weakness
- Paresthesias (Pins and Needles)
- Diplopia
- Difficulty Speaking
- Dysphagia
- Labile Blood Pressure
- Loss of Bowel and Bladder Control
- Considerations
- Aggressive Airway Management
2 mins
Myasthenia Gravis
- Mechanism
- Antibodies to Acetylcholine Receptor
- Symptoms
- Ptosis
- Diplopia
- Weakness with Muscle Use
- Respiratory Death
- Thymus Associated
- Treatment
- Acetylcholinesterase Inhibitors
- Plasmapheresis
- Thymectomy
1 min
Myasthenia Gravis Assessment
- Weakness with Muscle Use
- Diplopia
- Ptosis
- Dysphagia
- Difficulty Speaking
- Fatigue
- Complications
- Cholinergic Crisis
- Overmedicated
- Myasthenic Crisis
- Not Enough Medication
- Respiratory Muscle Paralysis
2 mins
Lambert-Eaton Syndrome
- Mechanism
- Autoantibody to the Presynaptic Calcium Channel on Motor Neurons
- Inhibits Acetylcholine (ACh) Release at Neuromuscular Junction
- Paraneoplastic Syndrome
- Small Cell Lung Cancer
- Symptoms
- Proximal Muscle Weakness
- Improves with Muscle Use
- Autonomic Symptoms
- Extraocular Muscle Sparing
2 mins
Multiple Sclerosis Features and Mechanisms
- Features
- More Common in Women
- Presents in 20's and 30's
- Northern Europeans
- Mechanism
- Unknown mechanism, genetic factor
- HLA-DRB1
- Autoimmune Demyelination of CNS
- White Matter of Brain and Spinal Cord
- T Cell Mediated Inflammation
2 mins
Internuclear Ophthalmoplegia
- ETIOLOGY
- Multiple Sclerosis
- Medial Longitudinal Fasciculus
- Mechanism
- CN VI Nucleus
- CN III Nucleus
2 mins
Multiple Sclerosis Assessment
- Cause/Mechanism
- Nerve Fiber Demyelination
- Assessment
- Motor Issues
- Cerebellar Signs
- Fatigue
- Paresthesias
- Spasticity
- Urinary Incontinence
- Optic Neuritis
- Considerations
- Women Between 20-50 Years Old
- Relapse and Remission of Symptoms
2 mins
Multiple Sclerosis Interventions
- Drug Therapy
- Corticosteroids
- Interferon Beta
- Dimethyl Fumarate (Tecfidera)
- Fingolimod (Gilenya)
- Mitoxantrone (Novantrone)
- Natalizumab (Tysabri)
- Considerations
- Increase Exercise
- Identify Triggers
2 mins
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